The invention discloses a pleural cavity water seal drainage device, which comprises a drainage catheter, a negative pressure regulating valve, a water injection port of a negative pressure monitoring window, a supporting foot and a drainage joint. A hook is provided, and a sampling hole is provided inside the outer shell; the head of the drainage catheter is fixedly connected with a joint, the outside of the joint is wrapped and fixed by an antibacterial sheath, and the end of the drainage catheter is connected to the sampling hole; the surface of the outer shell is inlaid A panel, the panel is provided with a water injection port, and the water injection port is connected with the outer shell, the surface of the panel is provided with a negative pressure monitoring window, and the surface of the panel is marked with the water level line of the water seal cavity. The water-sealed drainage device for the chest cavity has the advantages of simple structure, easy manufacture, small volume, convenient portability, good drainage effect, safety and reliability; it has the function of preventing regurgitation, improves the safety factor of the device, and avoids retrograde infection inside the patient's chest cavity.