The invention relates to a directional hydraulic pressing penetration, permeability increase and outburst elimination method of a guide groove, which comprises the steps of (1) constructing a guide groove drill or the guide groove drill and control drills in a coal seam; (2) forming a guide groove in the guide groove drill in advance; (3) utilizing the guide groove drill or the control drills to perform hydraulic fractures, utilizing the guide groove and the control drills to perform directional control on the hydraulic fractures, enabling the coal body between the guide groove drill or the guide groove drill and the control drills to be pressed into penetration, forming multiple fractures among drills, and enabling a large amount of nickings to be brought out through the high-pressure water; and (4) after the fractures finish, enabling all the drills to be sealed and accessed into a drainage system, and beginning extraction. By means of the method, the number of pressing penetration of drills can be increased by 50%, the pressure relief scope of the coal seam is increased by over one time, the permeability of the coal seam is remarkably improved, gas extraction is increased by more than four times, measure drills can be reduced by about 60%, fore-pumping time is effectively reduced, area outburst elimination is achieved, and gas hazards can be reduced to the largest extent.