Preparation method of silver-carried multilayer film coating biliary tract support frame

A multi-layer film and biliary tract technology, applied in the direction of coatings, stents, packaging items, etc., can solve the problems of complexity, complex preparation methods of biliary stents, and the impact of bactericidal performance, so as to prolong the patency period and prevent retrograde infection of biliary tract Effect

Inactive Publication Date: 2013-09-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, polymer bactericides have their own complexity. The relative molecular weight and distribution of polymer bactericides, the morphology in solution or coating and the degree of cross-linking of polymers will have a great impact on the bactericidal performance.
[0008] Current reports on biliary stents, such as the Chinese invention patent with publication number CN1586655A, provide a method for preparing a multi-layer drug-composite degradable biliary stent visible under X-rays. However, one of the biliary stents described in this patent document is The preparation method is complicated, and the second is to effectively prevent restenosis and infection from the perspective of utilizing degradation

Method used

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  • Preparation method of silver-carried multilayer film coating biliary tract support frame
  • Preparation method of silver-carried multilayer film coating biliary tract support frame
  • Preparation method of silver-carried multilayer film coating biliary tract support frame

Examples

Experimental program
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Effect test

Embodiment 1

[0047] (1) Preparation of chitosan-loaded nano-silver solution: First, slowly add 0.0849g of silver nitrate into 50ml of chitosan solution (pre-adjusted with HCl to pH = 3.8), and then stir evenly to obtain a chitosan solution of 10mM silver ions. Dissolve 60mg of sodium borohydride in 20ml of triple distilled water, take 5ml and slowly add the above chitosan at a rate of 0.01ml per second. After the dropwise addition, continue to stir for 0.5h, and then process the solution with a microporous membrane to remove large-sized particles and prevent particle agglomeration, and take it immediately. Ultraviolet detection was used to characterize the synthesis results of nanosilver. The prepared chitosan-loaded nano-silver solution was stored in the refrigerator in the dark, and it was detected by ultraviolet light for different days. It was found that the peak position of the nano-silver in the first 8 days basically did not move, and was stable at 396nm, indicating that the prepare...

Embodiment 2

[0050] (1) Preparation of chitosan-loaded nano-silver solution: same as in Example 1, except that the prepared chitosan-loaded nano-silver solution has a concentration of 0.01 mg / ml.

[0051] (2) Preparation of silver-loaded multilayer film-coated biliary stent: drip heparin solution with a concentration of 0.01 mg / ml (pre-adjusted with hydrochloric acid to pH=3.8) into the metal biliary stent body, spin coating once, and drop three-distilled water into the metal biliary stent The stent body is spin-coated once, and this step is repeated once, and then the concentration of 0.01mg / ml chitosan-loaded nano-silver solution (pre-adjusted with hydrochloric acid to pH=3.8) is dropped into the metal biliary stent body, spin-coated once, and the cycle above process, obtain 20 layers of silver-loaded multilayer film-coated biliary stents with chitosan nano-silver layers and heparin layers alternately coated, the total thickness of the multilayer film coating is 100nm, wherein, each spin-...

Embodiment 3

[0053] (1) Preparation of chitosan-loaded nano-silver solution: same as in Example 1, except that the prepared chitosan-loaded nano-silver solution has a concentration of 10 mg / ml.

[0054] (2) Preparation of silver-loaded multilayer film-coated biliary stents: firstly, the positively charged PET polyester biliary stents were obtained by amination treatment with hexamethylenediamine small-molecule aminating reagent, and then heparin solution with a concentration of 5 mg / ml ( Pre-adjust the pH=3.8 with hydrochloric acid) into the PET polyester biliary stent, spin-coat once, drop three-distilled water into the gold PET polyester biliary stent, spin-coat once, and repeat this step once, and then add chitosan with a concentration of 10mg / ml Sugar-loaded nano-silver solution (pre-adjusted with hydrochloric acid to pH = 3.8) was dropped into the PET polyester biliary stent, spin-coated once, and the above process was repeated to obtain 18 layers of silver-loaded polysaccharides with ...

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Abstract

The invention relates to the field of a medical material, and in particular to a preparation method of a silver-carried multilayer film coating biliary tract support frame. The method comprises the steps of: dropping 0.01-5mg / ml heparin solution into a biliary tract support frame body, spin coating, dropping three-steaming water into the biliary tract support frame body, spin coating, dropping 0.01-10mg / ml chitosan nano silver-carried solution into the biliary tract support frame body, spin coating, and circulating the process to obtain the silver-carried multilayer film coating biliary tract support frame, wherein the rotation speed of the spin coating is 250-5000 revolutions, and the spin coating time is 10-50 seconds. The surface of the prepared silver-carried multilayer film coating biliary tract support frame is more flat, and the silver-carried multilayer film coating biliary tract support frame has the functions of anti-bacterium, anti-virus and anti-mycete, so that the unobstructed period of the biliary tract support frame can be prolonged, and the antidromic infection of the biliary tract can be avoided.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a method for preparing a silver-loaded multilayer film-coated biliary stent with antibacterial properties. Background technique [0002] Pathogenic microorganisms such as bacteria and fungi often cause pathological changes in body tissues, seriously threatening human physical and mental health. According to the statistics of the World Health Organization (WHO) in 1998, there were 52 million deaths worldwide in 1995, of which about 33% were caused by bacterial infections, and this proportion is still increasing today. Therefore, the development of medical antibacterial materials and products has received more and more attention. [0003] Medical antibacterial materials can effectively reduce the risk of the body getting sick by blocking, inhibiting or killing pathogenic microorganisms. A good medical antibacterial material should have the following characteristics: 1) The materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/16A61L31/10A61L33/10A61F2/82
Inventor 郑树森杨富春计剑秦运升朱琳吴健柴秦明周琳
Owner ZHEJIANG UNIV
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