Medicine controlled timing-released calcium phosphate cement powder containing various medicines

A technology of calcium phosphate bone cement and medicine, applied in the field of biomedical materials and medicine, can solve the problem that calcium phosphate bone cement is difficult to meet the clinical application, and achieve the effect of promoting bone healing, promoting bone tissue growth and preventing osteolysis

Inactive Publication Date: 2011-08-31
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing single-drug calcium phosphate bone cem...

Method used

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  • Medicine controlled timing-released calcium phosphate cement powder containing various medicines
  • Medicine controlled timing-released calcium phosphate cement powder containing various medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The calcium phosphate bone cement powder containing multiple drugs in the drug-controlled time-sequential release of this example is prepared by the following method:

[0031] In the process of wet synthesis of hydroxyapatite (HA) containing 7 grams of dry matter, a long-term release drug containing 1 gram of dry matter was added to the uniformly dispersed suspension—a traditional Chinese medicine that can promote blood circulation and promote bone tissue growth Salvianolic acid B from Salvia miltiorrhiza extract, mix evenly; then add gelatin containing 0.5 g of dry matter, after mixing evenly, add an excessive amount of cross-linking agent - glutaraldehyde to fully cross-link the gelatin, thereby utilizing the macromolecule - gelatin to The drug-loaded hydroxyapatite is precipitated for coating, then dried and ground to obtain the coating powder.

[0032] Take 8.5 grams of wrapping powder containing salvianolic acid B prepared in the previous step, combine with 24 gram...

Embodiment 2

[0036] The calcium phosphate bone cement powder containing multiple drugs in the drug-controlled time-sequential release of this example is prepared by the following method:

[0037] In the process of wet synthesis of calcium dihydrogen phosphate powder with a dry matter amount of 27 grams, 12 grams of long-term release drug-adriamycin and 13 grams of long-term release drug-drynaria fortunei were added to the suspension, and mixed evenly. Then dry the suspension blended by precipitation and grind the powder, add it to the solvent containing 10 grams of polyglycolide, which is a macromolecule for wrapping, and mix evenly, and use polyglycolide to treat the drug-loaded calcium dihydrogen phosphate wrapping, drying and grinding to obtain the medicine-containing wrapping powder.

[0038] Get a total of 62 grams of the wrapping powder prepared in the previous step, and mix them evenly with 9 grams of hydroxyapatite, 64 grams of β-type tricalcium phosphate, 7 grams of sufentanil and...

Embodiment 3

[0041] The calcium phosphate bone cement powder containing multiple drugs in the drug-controlled time-sequential release of this example is prepared by the following method:

[0042] In the process of wet synthesis of calcium carbonate containing 40 grams of dry matter, add long-term release medicine to the suspension-the Chinese medicine ligustrazine extract of 20 grams of dry matter, after fully mixing, add 10 grams of glucose, and add excess Glucose cross-linking agent—formaldehyde fully cross-links the glucose, then dries and grinds the wrapping powder, then adds the wrapping powder to a solvent of 10 grams of degradable polymer polyhydroxybutyrate for secondary wrapping, and finally dries, Grind it into powder to get the wrapping powder for secondary wrapping.

[0043] Take a total of 80 grams of the wrapping powder prepared in the previous step, add 10 grams of hydroxyapatite powder, 50 grams of β-type tricalcium phosphate powder, and release drugs in the early stage—5 g...

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PUM

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Abstract

The invention relates to medicine controlled timing-released calcium phosphate cement powder containing various medicines. The powder is prepared by precipitating and blending long-term released medicines with one component in the calcium phosphate cement powder, and carrying out polymer packaging to obtain packaging powder; and directly blending the packaging powder with other calcium phosphate components in the calcium phosphate cement powder and early released medicines, or blending the packaging powder with the early released medicines, a precipitate blend powder of another component in the calcium phosphate cement powder and other components in the calcium phosphate cement powder. The powder is applicable to filling and repairing bone defects, and the early released medicines and thelong-term released medicines carried by the powder can be released at different time sequences at the local bone defect for combined administration; the curative effect can be enhanced by a synergistic effect so as to promote bone healing and increase the clinical success rate of filling and repairing the bone defect; moreover, the side effect of the medicines on human bodies can be reduced, and thus the powder meets the clinical requirements for bone filling and repairing materials.

Description

technical field [0001] The invention relates to the fields of biomedical materials and medicines, in particular to calcium phosphate bone cement powder containing multiple medicines. Background technique [0002] Calcium Phosphate Cement (CPC) is a self-curing artificial bone replacement material developed by Brown and Chow in the mid-1980s (Brown WE, Chow LC. A new calcium phosphate setting cement. Journal Dental Research, 1983; 62:672). The composition of calcium phosphate bone cement includes solid phase and liquid phase, the solid phase is mainly composed of one or several calcium phosphate salts or a mixture of other calcium salts, and the liquid phase can be distilled water, dilute acid, serum, blood, phosphate buffer (PBS) etc. (Bohner M. Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements. Injury. 2000; 31: 37-47.). After more than 20 years of development, many calcium phosphate bone cements with different formulations have been formed. ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/54
Inventor 屈树新林孙忠郭悦华翁杰
Owner SOUTHWEST JIAOTONG UNIV
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