Injectable gel material of sodium alga acid-protein adhesive used for treating myocardial infarction and preparation method of injectable gel material

A technology of sodium alginate and myocardial infarction, applied in medical science, prosthesis, etc., can solve problems such as poor mechanical properties and poor compatibility with organisms, achieve strong mechanical properties and chemical stability, improve heart function, and output The effect of volume increase

Active Publication Date: 2011-09-14
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is to solve the technical problems of poor biocompatibility and poor mechanical properties of the existing injectable hydrogel cross-linked with calcium ions for the treatment of myocardial infarction, and provide alginic acid for the treatment of myocardial infarction Sodium-protein glue injectable gel material and preparation method thereof

Method used

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  • Injectable gel material of sodium alga acid-protein adhesive used for treating myocardial infarction and preparation method of injectable gel material
  • Injectable gel material of sodium alga acid-protein adhesive used for treating myocardial infarction and preparation method of injectable gel material
  • Injectable gel material of sodium alga acid-protein adhesive used for treating myocardial infarction and preparation method of injectable gel material

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specific Embodiment approach 1

[0010] Embodiment 1: The sodium alginate-protein glue injectable gel material used for the treatment of myocardial infarction in this embodiment is composed of sodium alginate components and protein glue components mixed in a volume ratio of 1:0.5~3 Made; the protein glue component is prepared with gelatin or collagen into a solution with a concentration of 1% to 30% (mass), and the sodium alginate component is prepared by dissolving partially oxidized sodium alginate into a solvent A solution with a solubility of 5% to 60% (mass), the partially oxidized sodium alginate is composed of 1 part by mass of sodium alginate with a viscosity of 5mPa·s to 15mPa·s, 0.05 to 1 part of high Sodium iodate and 2 to 2.5 parts of sodium chloride and 1 g of ethylene glycol according to the mass volume ratio of sodium alginate to ethylene glycol: 1.5 mL to 1.8 mL of ethylene glycol, and 1 g according to the mass volume ratio of sodium alginate to ethanol : Made with 40mL~45mL of ethanol.

[00...

specific Embodiment approach 2

[0012] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the sodium alginate-protein gel injectable gel material used for the treatment of myocardial infarction is composed of sodium alginate component and gel component in a volume ratio of 1 : Mixed in a ratio of 1 to 2.8. Others are the same as the first embodiment.

specific Embodiment approach 3

[0013] Specific embodiment three: the difference between this embodiment and specific embodiment one is that the sodium alginate-protein gel injectable gel material used for the treatment of myocardial infarction is composed of sodium alginate component and gel component in a volume ratio of 1 : 2 ratio mixed made. Others are the same as the first embodiment.

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Abstract

The invention discloses a preparation method of an injectable gel material of sodium alga acid-protein adhesive used for treating myocardial infarction, relating to injectable hydrogelin and a preparation method of the hydrogelin. The material and the method solve the technical problems of the existing injectable hydrogelin using calcium ion for crosslinking such as poor compatibility with organisms and undesirable mechanical property. The injectable gel material of sodium alga acid-protein adhesive used for treating myocardial infarction is made from the component sodium alga acid and the component protein adhesive that are mixed. The preparation method includes: adding sodium alga acid in water to oscillate with light avoidance on a table concentrator, thus generating partially oxidized sodium alga acid solution; adding glycol to the solution and placed on the table concentrator to oscillate, then adding sodium chloride to oscillate, dissolve and precipitate, dissolving the precipitate in water to attain collosol, and dialyzing and freeze-drying to obtain partially oxidized sodium alga acid; formulating the sodium alga acid solution to obtain sodium alga acid component; formulating gelatin or collagen to obtain protein adhesive component; and mixing the sodium alga acid component with the protein adhesive component for use. The injectable gel material can be used for treating myocardial infarction.

Description

technical field [0001] The present invention relates to injectable hydrogels and methods for their preparation. Background technique [0002] Myocardial infarction and the resulting heart failure are the main causes of human death in industrialized countries. In the United States, there are more than 600,000 patients every year. In China, the number of people who die of myocardial infarction and its complications every year has exceeded 1 million. There are about 40 million coronary heart diseases in the country. Patients, about 260 patients died of cardiovascular and cerebrovascular diseases every hour. Among them, chronic heart failure and myocardial infarction account for more than 50% of cardiovascular deaths, and myocardial infarction has attracted great attention. [0003] When the cardiovascular is blocked, the myocardium is irreversibly damaged and cannot regenerate. As a result, the myocardial cells in the infarct area die, and the fibroblasts proliferate to form s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/26A61L27/22A61L27/20
Inventor 田维明李钰房蕊郑红霞
Owner HARBIN INST OF TECH
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