Injectable gel material of sodium alga acid-protein adhesive used for treating myocardial infarction and preparation method of injectable gel material

A technology of sodium alginate and myocardial infarction, applied in medical science, prosthesis, etc., can solve problems such as poor mechanical properties and poor compatibility with organisms, achieve strong mechanical properties and chemical stability, improve heart function, and output The effect of volume increase
CN102178984AActive Publication Date: 2011-09-14HARBIN INST OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN INST OF TECH
Publication Date
2011-09-14

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Abstract

The invention discloses a preparation method of an injectable gel material of sodium alga acid-protein adhesive used for treating myocardial infarction, relating to injectable hydrogelin and a preparation method of the hydrogelin. The material and the method solve the technical problems of the existing injectable hydrogelin using calcium ion for crosslinking such as poor compatibility with organisms and undesirable mechanical property. The injectable gel material of sodium alga acid-protein adhesive used for treating myocardial infarction is made from the component sodium alga acid and the component protein adhesive that are mixed. The preparation method includes: adding sodium alga acid in water to oscillate with light avoidance on a table concentrator, thus generating partially oxidized sodium alga acid solution; adding glycol to the solution and placed on the table concentrator to oscillate, then adding sodium chloride to oscillate, dissolve and precipitate, dissolving the precipitate in water to attain collosol, and dialyzing and freeze-drying to obtain partially oxidized sodium alga acid; formulating the sodium alga acid solution to obtain sodium alga acid component; formulating gelatin or collagen to obtain protein adhesive component; and mixing the sodium alga acid component with the protein adhesive component for use. The injectable gel material can be used for treating myocardial infarction.
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Description

technical field

[0001] The present invention relates to injectable hydrogels and methods for their preparation. Background technique

[0002] Myocardial infarction and the resulting heart failure are the main causes of human death in industrialized countries. In the United States, there are more than 600,000 patients every year. In China, the number of people who die of myocardial infarction and its complications every year has exceeded 1 million. There are about 40 million coronary heart diseases in the country. Patients, about 260 patients died of cardiovascular and cerebrovascular diseases every hour. Among them, chronic heart failure and myocardial infarction account for more than 50% of cardiovascular deaths, and myocardial infarction has attracted great attention.

[0003] When the cardiovascular is blocked, the myocardium is irreversibly damaged and cannot regenerate. As a result, the myocardial cells in the infarct area die, and the fibroblasts proliferate to form s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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