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New glue dissolving technology of soft capsules

A soft capsule and new technology technology, applied in the field of soft capsule sol technology in the pharmaceutical industry, can solve problems such as glue quality and achieve the effect of accelerating the melting process

Inactive Publication Date: 2011-10-19
贵州地道药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite the advanced auxiliary equipment, due to the different control of the sol process technology adopted by various enterprises and the related factors involved in the sol, various glue quality problems have been caused.

Method used

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  • New glue dissolving technology of soft capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Open the feeding port, put in the weighed purified water, glycerin, and sorbitol according to the sol formula, close the feeding port, start stirring, and raise the temperature of the mixed solution to 62°C, and keep the temperature of the interlayer water at 60°C during the entire sol process ℃~80℃.

[0033] (2) Open the feeding port, slowly add gelatin into the sol tank while stirring, and control the speed of glue feeding to avoid gelatin agglomeration and affect the effect of gelatinization. After the glue feeding is completed, close the feeding port and lock it tightly, and turn on the vacuum pump to vacuumize the negative pressure sol.

[0034] (3) During the sol process, observe the conditions in the tank and the changes in temperature and pressure at all times to prevent the glue from being sucked away. After the pressure reaches -0.06Mpa, turn off the vacuum pump and maintain this negative pressure for 45 minutes. Break the vacuum to observe that the gela...

Embodiment 2

[0038] (1) Open the feeding port, put in the weighed purified water, glycerin, and sorbitol according to the sol formula, close the feeding port, start stirring, and raise the temperature of the mixed solution to 65°C, and keep the temperature of the interlayer water at 60°C during the entire sol process ℃~80℃.

[0039] (2) Open the feeding port, slowly add gelatin into the sol tank while stirring, and control the speed of glue feeding to avoid gelatin agglomeration and affect the effect of gelatinization. After the glue feeding is completed, close the feeding port and lock it tightly, and turn on the vacuum pump to vacuumize the negative pressure sol.

[0040] (3) During the sol process, observe the conditions in the tank and the changes in temperature and pressure at all times to prevent the glue from being sucked away. After the pressure reaches -0.06Mpa, turn off the vacuum pump and maintain the negative pressure for 40 minutes. Break the vacuum to observe that the gelat...

Embodiment 3

[0044] (1) Open the feeding port, put in the weighed purified water, glycerin, and sorbitol according to the sol formula, close the feeding port, start stirring, and raise the temperature of the mixed solution to 68°C, and keep the temperature of the interlayer water at 60°C during the entire sol process ℃~80℃.

[0045] (2) Open the feeding port, slowly add gelatin into the sol tank while stirring, and control the speed of glue feeding to avoid gelatin agglomeration and affect the effect of gelatinization. After the glue feeding is completed, close the feeding port and lock it tightly, and turn on the vacuum pump to vacuumize the negative pressure sol.

[0046] (3) During the sol process, observe the conditions in the tank and the changes in temperature and pressure at all times to prevent the glue from being sucked away. After the pressure reaches -0.06Mpa, turn off the vacuum pump and maintain the negative pressure for 50 minutes. Break the vacuum to observe that the gelat...

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Abstract

The invention provides a new glue dissolving technology of soft capsules. On the basis of utilizing advanced auxiliary equipment, the glue dissolving temperature in a tank is controlled to be 50 DEG C-75 DEG C and the negative pressure is further kept at minus 0.04MPa to minus 0.08MPa for 40-80 minutes in the glue dissolving process, and heat insulation and standing are performed for 4-6 hours at the temperature of 55 DEG C-60 DEG C after glue dissolving is completed. By adopting the new method of the glue dissolving technology, the quality of glue solution can be improved, the technology is stable, the new technology is conductive to pressing the soft capsules, and the product quality is further ensured.

Description

Technical field: [0001] The invention relates to a new technology of soft capsule sol process, in particular to a new method of soft capsule sol process in the pharmaceutical industry. Background technique: [0002] The stability of soft capsules not only depends on the stability of soft capsules during the pressing process, the sol process is the key to the stability of soft capsules, which plays a decisive role in the stability of pressed capsules and the later stage of capsules, and its advantages and disadvantages directly affect the product. Quality, the traditional sol process is mainly based on simple equipment configuration and manual operation, and the sol method centered on the glue boiling process, which is characterized by heating in an open pot, manual stirring, and degassing mainly by standing and natural stratification. In the modern colloidal sol process, the upper opening is used to feed the sealed jacket to heat the plastic tank, the mechanical stirring dev...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/42
Inventor 路祖强
Owner 贵州地道药业有限公司
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