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Application of Esculentoside A in preparing drugs for controlling hepatic fibrosis or cirrhosis

A technology for pokeweed saponin A and liver fibrosis, which is applied in the field of medicine and can solve problems such as no pokeweed saponin A

Active Publication Date: 2011-10-19
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But so far there is no report about pokeweed saponin A having the activity of preventing and treating liver fibrosis or liver cirrhosis

Method used

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  • Application of Esculentoside A in preparing drugs for controlling hepatic fibrosis or cirrhosis
  • Application of Esculentoside A in preparing drugs for controlling hepatic fibrosis or cirrhosis
  • Application of Esculentoside A in preparing drugs for controlling hepatic fibrosis or cirrhosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1. Therapeutic effect of pokeweed saponin A on liver fibrosis

[0021] Animals: Male SD rats were purchased from the Experimental Animal Center of the Chinese Academy of Sciences in Shanghai (SPF grade).

[0022] Reagent: Dimethylnitrosamine (DMN), Tianjin Institute of Biotechnology.

[0023] Drug: Pokeweed Saponin A (EsA), self-made, see the preparation method: Yi Yanghua, Wang Lu. Study on the active components of pokeweed II Isolation and identification of triterpene saponins. Journal of the Second Military Medical University 1984, Supplement, 71.

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Abstract

The invention which belongs to the technical field of medicine relates to a new use of Esculentoside A in preparing drugs for controlling hepatic fibrosis or cirrhosis. Pharmacological experiments show that: Esculentoside A allows the generation of collagen in hepatic tissues to be substantially inhibited, the fibrosis degree to be reduced and the control effect on hepatic fibrosis and cirrhosis to be fine, so Esculentoside A can be used to prepare the drugs for controlling hepatic fibrosis or cirrhosis. The invention provides a new drug resource for controlling hepatic fibrosis or cirrhosis.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a new application of pokeweed saponin A in the preparation of drugs for preventing and treating liver fibrosis or liver cirrhosis. Background technique [0002] Phytolacca acinsa, a traditional Chinese medicine, has a long history of application and has been included in previous Chinese Pharmacopoeias. Phytolacca is bitter and cold in nature, and returns to the lung, spleen, kidney, and large intestine channels. Chinese medicine believes that it has the effect of dispelling water, reducing swelling, detoxifying and dispelling stagnation. Over the years, more than 30 pokeweed saponins have been isolated and identified, 18 of which are new compounds. [0003] Esculentoside A (Esculentoside A, EsA) is one of the main active ingredients in pokeweed saponin, and its chemical structure is as follows: [0004] [0005] Pokeweed saponin A is a good COX-II inhibitor, which has the effect of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P1/16
Inventor 张文易杨华刘宝姝汤华李玲孙鹏
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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