Medicine for treating coronary heart disease
A technology for coronary heart disease and a composition, which is applied in the field of drugs for the treatment of coronary heart disease, can solve the problems of no-reflow and remodeling of the myocardium, and achieve the effect of improving the level of innovation and international competitiveness.
Active Publication Date: 2012-12-26
PEKING UNIV FIRST HOSPITAL
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Problems solved by technology
Although modern medicine has made significant progress in drug intervention and interventional therapy, many clinical problems remain unsolved, such as myocardial no-reflow after reperfusion, ventricular remodeling after myocardial infarction, etc.
Method used
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Embodiment 1
[0018] Example 1. Chinese medicine formula
[0019] 1. Animal experiment method-anti-myocardial ischemia effect:
[0020] (1) Experimental animals: 140 healthy and clean Wistar rats, weighing 180±20g, male.
[0021] (2) Experimental drugs: Xiyang participates in 5 formulations of Yuanhu. The quality ratio is as follows:
[0022] American ginseng decoction pieces were purchased from Guangzhou Kangmei Pharmaceutical Co., Ltd., the product catalog number is 20101205, and the average content of the active ingredients (that is, the total saponins of American ginseng) is 4.30%.
[0023] The vinegar-roasted Corydalis decoction pieces were purchased from Beijing Weiren Traditional Chinese Medicine Decoction Pieces Factory, the product catalog number is 103209201, and the average content of its active ingredient (ie tetrahydropalmatine) is 0.105%.
[0024] American ginseng decoction pieces: vinegar-roasted Corydalis decoction pieces = 2:1, that is, the effective ingredients in American ginseng d...
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The invention discloses a medicine for treating coronary heart disease. In the product of the invention for preventing and / or treating coronary heart disease, the active ingredients thereof are composed of panax quinquefolium saponin and tetrahydropalmatine. The experiment proves that compatible American ginseng and rhizoma corydalis can be used for efficiently treating myocardial ischemia; therefore, American ginseng and rhizoma corydalis can be used for preventing and / or treating coronary heart disease. The technique method for preparing the alkaloidal compatible preparation of panax quinquefolium saponin and rhizoma corydalis is stable, the extraction rate of active ingredients is high, and the medicine is suitable for industrial production. The medicine of the invention establishes a technical platform for the research and development of innovative traditional Chinese medicines for coronary heart disease in the aspects of the safety, efficacy evaluation, pharmacokinetics and the like of compound traditional Chinese medicine, which is good for developing new traditional Chinese medicines with good clinical application prospect and market competitiveness, and further increases the innovation level and international competitiveness of new domestic medicines.
Description
Technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for treating coronary heart disease. Background technique [0002] Coronary heart disease is a major disease that seriously threatens human health and life. Its morbidity and mortality are increasing year by year, and it has brought a heavy medical burden to society. It is a major public health problem in my country. Therefore, the prevention and treatment of coronary heart disease is crucial important. Although modern medicine has made significant progress in drug intervention and interventional therapy, many clinical problems have not been resolved, such as myocardial no reflow after reperfusion and ventricular remodeling after myocardial infarction. Many therapeutic principles and clinical effectiveness of Chinese medicine, such as replenishing qi and promoting blood circulation, removing blood stasis and creating newness, have great potential for relieving an...
Claims
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IPC IPC(8): A61K31/704A61K31/4375A61K36/258A61K36/50A61P9/10
Inventor 刘梅林
Owner PEKING UNIV FIRST HOSPITAL