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Application of a natural medicinal composition in the preparation of hypoxia-resistant medicines and health care products
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A technology of natural medicine and composition, applied in the field of medicine, to achieve the effect of improving hypoxia tolerance, high utilization value, and definite activity
Inactive Publication Date: 2016-01-20
JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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[0008] Before the completion of the present invention, it has not been found that the composition composed of American ginseng flower saponin extracted from American ginseng flower, centella asiaticoside extracted from Centella asiatica, paeoniflorin extracted from red peony and orange red total flavonoids extracted from orange red Reports on Improving Hypoxia Tolerance
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[0067] American ginseng flower 5kg, reflux extraction with 10 times the amount of 60% ethanol for 2 times, each time for 2 hours, filter, recover ethanol from the filtrate to obtain ethanol extract, add water to contain 0.8g medicinal material per 1ml, stir well, pass through the pre-treated D -101 macroporous resin column, first eluted with deionized water for 5 times the column volume, discarded the eluent, then eluted with 70% ethanol for 4 times the column volume, collected the eluate, recovered the ethanol, dried, and obtained American ginseng flower saponins. Ginsenoside Rb 1 As a reference substance, the content of total saponins was 83.9% as determined by ultravioletspectrophotometry.
Embodiment 2
[0068] Embodiment 2, Preparation of asiaticoside
[0069] Centella asiatica 20kg, extracted twice with 10 times the amount of deionized water, 2 hours each time, filtered, the filtrate was concentrated to contain 1.0g medicinal material per 1ml, passed through the D101 macroporous resin column that had been treated, and deionized water Elute 5 times the column volume, discard the eluent, continue to elute with 70% ethanol for 5 times the column volume, collect the eluate, recover the ethanol eluate, dry it, and obtain asiaticoside. Madecassoside and asiaticoside were used as reference substances, and the total content of madecassoside was 62.6% based on madecassoside and asiaticoside.
[0071]Radix Paeoniae Rubra 20kg, extracted 3 times with 8 times the amount of deionized water, 2 hours each time, filtered, the filtrate was concentrated to contain 0.5g medicinal material per 1ml, the concentrated solution was passed through a pre-treated polyamide column, and eluted with water for 3 times the column volume , collect the effluent and eluent, concentrate, the concentrated solution is passed through a pre-treated D101 macroporous resin column, first eluted with deionized water for 4 times the column volume, discarded the eluent, and then eluted with 50% ethanol , recover the ethanol eluate, dry it, and get paeoniflorin; take paeoniflorin as the reference substance, and use high-performance liquid chromatography to determine the content of paeoniflorin is 86.9%. Embodiment 4, Preparation of total flavonoids of orange red
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Abstract
A natural medicinal composition that helps hypoxia tolerance, characterized in that for the first time anti-inflammatory and anti-exudative asiaticoside and paeoniflorin are combined with anti-ischemia and hypoxia American ginseng saponins and orange red total saponins Formed from a prescription, the effective substance of the composition is clear and quality-controllable, and the synergistic effect of each component is fully utilized. In addition to considering the material basis of anti-ischemia and hypoxia in the composition of the prescription, the more outstanding contribution of the present invention lies in the consideration of the prevention and treatment of acute inflammatory exudation caused by ischemia and hypoxia to cardiovascular and cerebrovascular tissues. It can be made into oral preparations, such as hard capsules, tablets, granules, powders, pills, teabags, and oral liquids. The composition can be used in Chinese patent medicines or health foods that help improve hypoxia tolerance.
Description
technical field [0001] The invention relates to a pharmaceutical composition and a preparation method helpful for improving hypoxia tolerance, which belong to the technical field of medicine. Background technique [0002] Oxygen is an important condition for the survival of human beings and many organisms. When the oxygen required by the body's vital activities cannot be supplied adequately, it is called hypoxia or hypoxia. Hypoxia will cause abnormal changes in body metabolism, function, and even morphological structure. Severe or long-term hypoxia will bring serious harm to the body, and eventually lead to the death of important organs such as the heart and brain due to insufficient energy supply. Oxygen and hypoxia are important topics in the basic theory of life sciences. The formation of hypoxia can be divided into three categories: the first category is the reduction of oxygen content in the external environment, which makes it impossible to take in enough oxygen du...
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