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Pharmaceutical composition comprising ibuprofen, pseudoephedrine and chlorpheniramine

A technique for pseudoephedrine and composition, applied in the field of pharmaceutical compositions, can solve the problems of low bioavailability, low plasma absorption and solubility, adverse effects and the like

Inactive Publication Date: 2011-11-30
博科药物化学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The acidic nature of ibuprofen as described in US5071643 and US5360615 can cause adverse effects on the stomach lining of users who are very sensitive to the acidic components of the drug
In addition, ibuprofen with acidic properties will have lower bioavailability due to lower plasma absorption and solubility

Method used

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  • Pharmaceutical composition comprising ibuprofen, pseudoephedrine and chlorpheniramine
  • Pharmaceutical composition comprising ibuprofen, pseudoephedrine and chlorpheniramine
  • Pharmaceutical composition comprising ibuprofen, pseudoephedrine and chlorpheniramine

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Experimental program
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Embodiment 1

[0014]

Embodiment 2

[0016]

Embodiment 3

[0018]

[0019]

[0020] The steps for preparing 500L of the pharmaceutical composition of the present invention are listed below:

[0021] 300 L of deionized water was added to a production vessel and heated. 200 kg of sugar was added thereto, the stirrer was turned on, the sugar was completely dissolved, and transferred to an auxiliary vessel.

[0022] Dissolve 500 g of sodium methylparaben in 20 L of deionized water and add to the container.

[0023] Add 50L of water in the auxiliary container, then add 9kg of sodium bicarbonate and 10kg of ibuprofen to prepare ibuprofen sodium salt, which is transferred to the manufacturing container.

[0024] Add 10 kg of deionized water to the auxiliary container. Add 1.5 kg pseudoephedrine HCL and 0.1 kg chlorpheniramine, dissolve, and transfer to the manufacturing container.

[0025] Add 100kg of glycerin to the manufacturing container.

[0026] 245 g of sunset yellow dissolved in 20 L of water was added to the reaction.

[...

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Abstract

The present invention relates to a pharmaceutical composition comprising ibuprofen as the active agent, preferably chloropheniramine maleate as an antihistaminic agent, preferably pseudoephedrine HCl as a sympathomimetic amine, and an alkaline salt, such as sodium bicarbonate, in an amount adequate to maintain the final solution's pH level between 7 and 9.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, comprising active ingredient iprofen, antihistamine chlorpheniramine, sympathetic nervous stimulant amine pseudoephedrine HCl, and alkaline salt, such as to make the pH of the final solution between 7-9 Between the amount of sodium bicarbonate. Background technique [0002] Ibuprofen is a drug ingredient known to have analgesic, anti-inflammatory and antipyretic properties. For example, a pharmaceutical composition comprising it and pseudoephedrine is disclosed in US5100675, which can relieve flu symptoms and symptoms of cold, fever, sinusitis, or nasal congestion, headache and general malaise. [0003] US5071643 and US5360615 disclose a kind of solvent system that is used to prepare high-concentration medicament, comprises the high-concentration solution of acidic medicament, wherein contains the ibuprofen of tablet or soft capsule or capsule. According to the solution of US5071643 relat...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K31/192A61K31/4402A61P31/16A61P11/02A61K9/00
CPCA61K31/4402A61K9/0095A61K31/137A61K31/192A61P11/02A61P31/16A61K2300/00
Inventor M·勃兰特·伯恩
Owner 博科药物化学有限公司
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