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A kind of acetylisovaleryl tylosin nanoemulsion drug and preparation method thereof

A technology of acetylisovaleryl tylosin and acetylisovaleryl tylosin, which is applied in the field of medicine, can solve the problems of low bioavailability, easy drug resistance, and large dosage, and achieve improved solubility and good growth rate. Solvent effect and high thermodynamic stability

Inactive Publication Date: 2011-12-14
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bioavailability of this dosage form is low, the dosage is large, and drug resistance is prone to occur.

Method used

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  • A kind of acetylisovaleryl tylosin nanoemulsion drug and preparation method thereof
  • A kind of acetylisovaleryl tylosin nanoemulsion drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] According to the law of 9:1~1:9, the selected oil, surfactant and co-surfactant are selected by calculating the HLB value, and the pseudo-ternary phase diagram is drawn to determine the optimal ratio. Accurately weigh 2.0 g of Tween-80, 0.2 g of propylene glycol, 0.2 g of isopropyl myristate, 0.001 g of acetylisovaleryl tylosin, and the balance is distilled water. Under room temperature conditions of 25°C, mix Tween-80, propylene glycol, isopropyl myristate, and acetylisovaleryl tylosin thoroughly with manual stirring as the oil phase, and then slowly add distilled water to it, adding it manually Stir, the viscosity of the system is small at the beginning, as the amount of distilled water increases, the system will become viscous, at this time the system may appear liquid crystal state or water-in-oil nanoemulsion, continue to drop and stir continuously, when the system suddenly becomes thinner , what is produced at this time is a stable yellow transparent acetylis...

Embodiment 2

[0054] RH-40 3.6g, ethanol 0.5g, propylene glycol 0.5g, ethyl acetate 0.5g, acetylisovaleryl tylosin 0.05g, distilled water 4.85g.

Embodiment 3

[0056] EL-40 1.5g, ethanol 0.3g, oleic acid 0.2g, acetylisovaleryl tylosin 0.005g, distilled water 7.995g.

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Abstract

The invention discloses an acetylisovaleryl tylosin nanoemulsion anti-mycoplasma drug. The diameter of the nanoemulsion droplets is between 1 and 100 nm, and is composed of the following raw materials in mass percentage: 15.00% to 36.00% of surfactant, Co-surfactant 2.00%-20.00%, oil 1.00%-5.00%, acetylisovaleryl tylosin 0.01%-2.00%, the balance is distilled water, and the sum of the mass percentages of the above raw materials is 100%. The invention improves the drug stability of the acetylisovaleryl tylosin, improves the bioavailability of the acetylisovaleryl tylosin, delays its drug metabolism time in the body, reduces the adjuvant dosage, reduces the production cost, and is used in medicine. The field has broad market prospects.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of medicine, in particular to a transparent and stable acetylisovaleryl tylosin nanoemulsion medicine and a preparation method thereof. Background technique [0002] Acetylisovaleryl tylosin, also known as tyvanectin, as a new macrolide antibiotic, is a brand-new macrolide antibiotic commercialized by the British Yike Animal Health Products Co., Ltd., through microbial The transformation is obtained by acetylating the third position and isovalerylation at the fourth position of tylosin, which is of breakthrough significance. Tivalamectin has good activity against macrolide-sensitive bacteria and drug-resistant respiratory disease pathogens, overcomes the shortcomings of many macrolides, has high efficiency, broad-spectrum, is not easy to produce drug resistance, and is highly toxic. With the characteristics of small side effects, it has become a good antibiotic for clinica...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/7048A61K47/44A61K47/26A61P31/04A61P11/00A61P1/00
Inventor 欧阳五庆宋冰欧阳伸雨
Owner NORTHWEST A & F UNIV
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