Preparation technology and production method of a new integrated dosage form of Wuwei Xiaoxiaoyin

The technology of a five-flavor disinfection drink and a production method is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effects of strong sustained and controlled release performance and wide targeted distribution.

Inactive Publication Date: 2011-12-21
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chlorogenic acid has an allergenic effect and can cause allergic reactions, but there is no such reaction when tak

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0043] [Example 1]

[0044] The following raw materials were prepared according to the aforementioned method: extract, nanoparticles, microcapsules, and nanoparticles.

[0045] The raw material composition of the active ingredients is as follows: 15 parts of honeysuckle, 12 parts of wild chrysanthemum, 12 parts of dandelion, 15 parts of Viola dianthaceae, and 6 parts of Tiankui.

[0046] The manufacturing process is as follows: After mixing the extract, nanoparticles, microcapsules, and nanoparticles in a 4:2:2:2 ratio in a GMP10000 clean room, use the 2010 edition of the "Chinese Pharmacopoeia" Part I of the preparations and hard capsules Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with an automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, sticking labels, coding, and packing. Finally, uniform instant sterilization according to the production bat...

Example Embodiment

[0047] [Example 2]

[0048] The following raw materials were prepared according to the aforementioned method: decoction concentrate, nano liposomes, nano emulsions, and micro emulsions.

[0049] The raw material composition of the active ingredients is as follows: 15 parts of honeysuckle, 12 parts of wild chrysanthemum, 12 parts of dandelion, 15 parts of Viola dianthaceae, and 6 parts of Tiankui.

[0050] The manufacturing process is as follows: After mixing the decoction concentrate, nanoliposomes, nanoemulsions, and microemulsions at a ratio of 4:2:2:2 in a GMP10000 clean room, use the first preparation of the 2010 Chinese Pharmacopoeia Part of the soft capsule standard does not add auxiliary materials and preservatives. The soft capsule is filled with an automatic soft capsule filling machine to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, sticking labels, coding, and packing. Finally, uniform instant sterilization accor...

Example Embodiment

[0051] 〖Example three〗

[0052] The following raw materials were prepared according to the aforementioned method: extract, nano-particles, and nano-emulsion.

[0053] The raw material composition of the active ingredients is as follows: 15 parts of honeysuckle, 12 parts of wild chrysanthemum, 12 parts of dandelion, 15 parts of Viola dichotoma, and 6 parts of Tiankui.

[0054] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, adopt the 2010 edition of the "Chinese Pharmacopoeia" Part I of the preparation and partial film standards, and the film forming materials are used Polyvinyl alcohol, made into film. Then carry out inner and outer packaging such as boxing, sealing, sticking labels, coding, and boxing. Finally, uniform instant sterilization according to the production batch, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, and each film is applied fo...

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Abstract

The invention relates to a preparation technology and production method of a new integrated dosage form of Wuwei Xiaoxiaoyin. The raw material composition of the active ingredients is as follows: 15 parts of honeysuckle, 12 parts of wild chrysanthemum, 12 parts of dandelion, 15 parts of Viola chinensis, 6 parts of purple geranium. Its production process includes: supersonic jet pulverization, alcohol water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure emulsification, nano particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Wuwei disinfection drink, and also relates to a preparation technology of a new integrated dosage form of Wuwei disinfection drink and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysi...

Claims

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Application Information

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IPC IPC(8): A61K36/86A61K9/00A61P31/04A61P17/02
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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