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A traditional Chinese medicine compound preparation for alleviating toxic and side effects of radiotherapy and chemotherapy and its application

A compound preparation and a technology for toxic and side effects are applied in the preparation process and application field of traditional Chinese medicine compound preparations, and can solve problems such as damage to normal tissue cells and their functions, influence on treatment effects, and immunosuppression.

Active Publication Date: 2015-12-16
SHENYANG PHARMA UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapy is currently one of the most important methods in the comprehensive treatment of malignant tumors, but chemotherapy alone often causes immunosuppression, leading to repeated infections
While chemotherapy kills tumor cells, it also damages normal tissue cells and their functions, thus affecting the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Prescription Screening

[0023] Prescription screening was carried out using experimental mice with glacial acetic acid gastric ulcer as a model.

[0024] 1. Experimental materials

[0025] Experimental animals: 90 healthy mice, half male and half female, weighing 18-22 g; provided by the Animal Experiment Center of Shenyang Pharmaceutical University.

[0026] Reagent: formaldehyde solution: Liaohe Chemical Factory, Sujiatun District, Shenyang City Batch number: 20051101

[0027] Sodium chloride injection: Shenyang Zhiying Pharmaceutical Factory Batch number: 07082803

[0028] Sodium carboxymethyl cellulose 800-1200: Tianjin Bodi Chemical Co., Ltd. Batch number: 20061018

[0029] Glacial acetic acid: Tianjin Bodi Chemical Co., Ltd. Batch number: 20070720

[0030] Drugs: pinellia, ginger, skullcap, berberine, ginseng, astragalus, licorice, and jujube are in compliance with the Pharmacopoeia of the People's Republic of China.

[0031] Cimetidine tablets: S...

Embodiment 2

[0053] Example 2: 18 parts of pinellia, 12 parts of ginger, 3 parts of berberine, 6 parts of skullcap, 9 parts of ginseng, 9 parts of licorice, and 12 parts of jujube.

[0054] Mix pinellia, ginger, ginseng, berberine, scutellaria, licorice, and jujube according to the weight ratio, add 8 times the amount of water to soak for 12 hours, heat and reflux extraction 3 times, each time for 30 minutes. The extracts were combined, concentrated under reduced pressure at 50°C to a certain volume, and transferred to a desiccator under reduced pressure at 50°C to dry extract powder. Extract powder: microcrystalline cellulose: lactose (16:1:1) mixed evenly, 70% ethanol passed through a 14-mesh sieve to make wet granules, dried below 50°C, passed through a 16-mesh sieve for granulation, and compound F1 was obtained.

Embodiment 3

[0055] Example 3: 18 parts of pinellia, 12 parts of ginger, 3 parts of berberine, 6 parts of skullcap, 9 parts of ginseng, 9 parts of licorice, and 12 parts of jujube.

[0056] Coptis chinensis is first decocted with 8 times the amount of water, and concentrated to obtain clear ointment A; ginger is co-distilled with 8 times the amount of water to obtain volatile oil, which is clathrated with cyclodextrin to obtain inclusion compound B, and the remaining medicinal juice and dregs are mixed with the remaining five herbs. Decoct with 6-10 times the amount of water and concentrate to obtain clear paste C. Mix clear pastes A and C, concentrate and dry at 50°C to obtain extract powder, add B and mix evenly, mix evenly with the ratio of extract powder: microcrystalline cellulose: lactose (16:1:1), and use 70% ethanol as Wetting agent, made of soft materials, passed through a 14-mesh sieve to prepare wet granules, dried, and sifted through a 16-mesh sieve to granulate, to obtain comp...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine compound preparation which is anti-ulcer and capable of alleviating toxic and side effects of radiotherapy and chemotherapy, and its preparation method and application. 3 to 10 parts of Scutellaria baicalensis, the above four herbs form the basic prescription, adjuvanted with one or more of the following traditional Chinese medicines by weight: 5 to 15 parts of ginseng, 20 to 35 parts of astragalus, 3 to 15 parts of licorice, 5 parts of jujube ~18 pieces. The present invention is a compound preparation obtained by screening prescriptions based on many years of clinical experience and optimizing the preparation process according to the theory of traditional Chinese medicine. This prescription has the effects of nourishing qi and harmonizing the stomach, combining cold and heat, dispelling mass and resolving stagnation, etc. It can be widely used in digestive system diseases such as ulcer disease, chronic gastritis, Helicobacter pylori gastropathy, enteritis, etc. The role of its definite curative effect, rapid effect, no toxic side effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, especially a preparation process and application of a traditional Chinese medicine compound preparation for treating peptic ulcer and exerting synergistic and attenuating effects when combined with chemotherapeutic drugs. Background technique [0002] Peptic ulcer, including gastric ulcer and duodenal ulcer, is a common and frequently-occurring disease of the digestive system in clinical practice, with a total incidence of about 10% to 20% of the total population. The main symptoms of peptic ulcer are chronic or periodic stomach area pain, belching, abdominal distension, acid reflux, etc., which can cause various complications, such as gastric bleeding, gastric perforation, gastric cancer, etc. It is a chronic and relapsing disease with a small mortality rate, but it brings great suffering to the patients. Therefore, the prevention and treatment of peptic ulcer disease is a key topic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P1/04A61P1/08A61P1/14
Inventor 殷军曹云峰薛睿韩娜
Owner SHENYANG PHARMA UNIVERSITY
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