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Method for accurately determining serum potassium

A technology for serum and potassium concentration, applied in measuring devices, material analysis through electromagnetic means, instruments, etc., can solve the problems of limited stable isotope sources, high prices, and restrictions on popularization and application, and achieve the effect of avoiding uncertain factors

Active Publication Date: 2013-05-01
BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
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AI Technical Summary

Problems solved by technology

but due to 41 The limited source of K stable isotope, difficult purchasing channels, and high price limit the popularization and application of this method.

Method used

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  • Method for accurately determining serum potassium
  • Method for accurately determining serum potassium
  • Method for accurately determining serum potassium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, with cobalt element as internal standard determination potassium content in serum

[0038] 1. Instruments and reagents

[0039] 1. Instrument

[0040] (1) PerkinElmer Elan DRC II inductively coupled plasma mass spectrometer (USA). Perform regular instrument maintenance.

[0041] (2) Mettler AE 1 / 400,000 (Max=200g, d=10 -4 g) balance (Mettler, Germany), used for the preparation of calibration solution and internal standard solution, and the accurate addition of internal standard in calibration solution, standard substance and serum samples.

[0042] (3) Milli-Q water purification device (Millipore, France) was used for the preparation of ultrapure deionized water for experiments. The Beijing Municipal Bureau of Metrology proofreads and inspects once a year.

[0043] (4) Eppendorf Reference pipettes: Proofreading and testing by Beijing Metrology Bureau once a year.

[0044] 2. Reagents

[0045] (1) Serum electrolyte standard substances: SRM956c levels...

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Abstract

The invention discloses a method for accurately determining serum potassium and provides a method for measuring potassium concentration in serum by an inductively coupled plasma mass spectrometry. In the method for measuring the potassium concentration in serum by the inductively coupled plasma mass spectrometry, a cobalt element is used as an internal standard, and the potassium concentration inthe serum is measured by the inductively coupled plasma mass spectrometry. The method simultaneously has the advantages of high detection speed, sensitivity and accuracy, low cost and the like, and asample is not needed to be separated quantitatively, so the method is recommended to be the reference method for measuring the serum potassium.

Description

technical field [0001] The invention relates to a method for accurately measuring serum potassium. Background technique [0002] Potassium is the main cation in the cell. Its main function is to maintain the normal osmotic pressure and acid-base balance of the body, participate in the metabolism of sugar and protein, and ensure the normal function of neuromuscular. Therefore, accurate determination of serum potassium is of great significance in clinical diagnosis. At present, the commonly used clinical detection methods include flame photometry, ion selective electrode (ISE) method, enzyme kinetics method and so on. With the increasing awareness of the comparability of measurement results, traceability research in biological and clinical chemistry has received more and more attention in the field of laboratory medicine. The deterministic method and reference method for the determination of serum potassium have been successively established in the world: in 1979, the Nationa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/62G01N27/626
Inventor 王清涛张瑞马怀安李慧玲
Owner BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
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