Freeze-dried preparation containing L-ascorbyl-2-phosphate-6-fatty acid, and its cosmetics

A technology of ascorbic acid and fatty acid, applied in cosmetics, cosmetics, cosmetic preparations and other directions, can solve the problems of deliquescence, design limitation, low water permeability, etc., and achieve the effect of large allowable range, high degree of freedom and good solubility

Inactive Publication Date: 2012-01-11
FUAN KERU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to this technology, L-ascorbic acid-2-phosphate-6-fatty acid can be stored stably at room temperature, and it is excellent in usability as an external skin preparation, but it tends to deliquesce after moisture absorption, so it needs to be stored in a place with low water permeability in containers such as glass containers
Glass containers are generally expensive and difficult to finely process compared to plastic containers, so designability is sometimes limited

Method used

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  • Freeze-dried preparation containing L-ascorbyl-2-phosphate-6-fatty acid, and its cosmetics
  • Freeze-dried preparation containing L-ascorbyl-2-phosphate-6-fatty acid, and its cosmetics
  • Freeze-dried preparation containing L-ascorbyl-2-phosphate-6-fatty acid, and its cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Freeze-dried formulation of trisodium L-ascorbyl-2-phosphate-6-palmitate (APPS(R)) in water with alanyl glutamine.

[0042] Dissolve 2.86g of APPS and 5.72g of alanylglutamine in 80g of water, and adjust the total amount to 100g with water. 3.5 g of this aqueous solution was filled into a vial, and freeze-dried to obtain about 0.3 g of a freeze-dried preparation of APPS and alanylglutamine. Alanyl Glutamine uses L-alanyl-L-glutamine.

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PUM

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Abstract

The invention provides stable L-ascorbyl-2-phosphate-6-fatty acid and the salt powder preparation thereof. The invention also provides the freeze-dried preparations of water solution containing L-ascorbyl-2-phosphate-6-fatty acid and L-alanyl-L-glutamine.

Description

technical field [0001] The present invention relates to a technique for stably blending L-ascorbic acid-2-phosphate-6-fatty acid into cosmetics. Background technique [0002] Ascorbic acid has the effects of inhibiting lipid peroxide, promoting collagen formation, delaying melanin formation, enhancing immune function, etc., and has been used in cosmetics and other fields for a long time. However, since ascorbic acid has poor stability over time and lacks fat solubility, it is difficult to permeate cell membranes, and the amount of accumulation in cells is limited, so that sufficient physiological effects cannot be obtained. L-ascorbic acid-2-phospho-6-palmitic acid and its salts, L-ascorbic acid-2-phospho-6-lauric acid and its salts or L- When ascorbic acid-2-phosphoric acid-6-stearic acid is applied to normal adult human breast epidermal keratinocytes, the derivatives of L-ascorbic acid (L-ascorbic acid-2-phosphate, 6- O-pivaloyl-L-ascorbic acid-3-phosphate, L-ascorbic ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61Q1/00A61Q19/00
CPCA61K8/36A61K8/55A61K8/676A61K2800/84A61Q19/00
Inventor 柜田广子森本裕史
Owner FUAN KERU
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