Wound healing agent and radix astragali composite freeze-dried platelet gel kit for preparing wound healing agent

A technology of platelets and gels, applied in the field of drug preparation, can solve problems such as limiting the application of PRP gels

Inactive Publication Date: 2012-01-18
霍红梅 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore above shortcoming limits the clinical application of PRP gel

Method used

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  • Wound healing agent and radix astragali composite freeze-dried platelet gel kit for preparing wound healing agent
  • Wound healing agent and radix astragali composite freeze-dried platelet gel kit for preparing wound healing agent
  • Wound healing agent and radix astragali composite freeze-dried platelet gel kit for preparing wound healing agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: A kind of wound healing agent and astragalus compound freeze-dried platelet gel kit for preparing wound healing agent

[0028] An astragalus compound freeze-dried platelet gel kit, which is composed of astragalus water extract solution, freeze-dried thrombin and freeze-dried platelets, the astragalus water extract solution, freeze-dried thrombin and freeze-dried platelets are stored separately; The concentration of the Astragalus water extract solution is that every milliliter of the Astragalus water extract solution contains 0.1 mg of astragaloside IV.

[0029] 1. The application method of wound healing agent is as follows:

[0030] A. Rehydration of freeze-dried platelets

[0031] Place the vial containing the freeze-dried platelets and the sterilized water bottle for injection in a water bath at 30-37°C to warm for several minutes. Draw 0.5ml of sterilized water for injection into the vial containing freeze-dried platelets with the syringe, put the v...

Embodiment 2

[0082] Embodiment 2: A kind of wound healing agent and astragalus composite freeze-dried platelet gel kit for preparing wound healing agent

[0083] An astragalus compound freeze-dried platelet gel kit, which is composed of astragalus water extract solution, freeze-dried thrombin and freeze-dried platelets, the astragalus water extract solution, freeze-dried thrombin and freeze-dried platelets are stored separately; The concentration of the Astragalus water extract solution is that every milliliter of the Astragalus water extract solution contains 0.1 mg of astragaloside IV. The freeze-dried platelet adopts a platelet concentration of 1×10 12 Plasma above individual / L was prepared by freeze-drying.

[0084] The preparation method of described wound healing agent is: mainly consists of the following steps:

[0085] The first step: mix freeze-dried platelets and sterile water for injection and place them in a water bath at 30-37°C to fully dissolve the freeze-dried platelets t...

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Abstract

A wound healing agent and a radix astragali composite freeze-dried platelet gel kit for preparing the wound healing agent. The kit comprises a radix astragali extract solution which is stored separately, freeze-dried thrombin and freeze-dried platelets. The preparation method of the wound healing agent mainly comprises the following steps: step one, mixing freeze-dried platelets and sterile injection water, placing the mixture in a water bath with a temperature of 30-37 DEG C, fully dissolving the freeze-dried platelets to obtain a freeze-dried platelet solution; adding freeze-dried thrombin into the radix astragali extract solution to obtain a composite thrombin solution; step two, well mixing the freeze-dried platelet solution and the composite thrombin solution to obtain the wound healing agent. In the invention, after the radix astragali extract solution is mixed with thrombin, the mixture has the effect of activating fibrinogen to become fibrin glue in vitro, and thus reaches theeffect of wound healing.

Description

technical field [0001] The invention relates to a wound healing agent and an astragalus composite freeze-dried platelet gel kit for preparing the wound healing agent, belonging to the technical field of medicine preparation. Background technique [0002] Wound healing is a complex biological process, especially the healing of chronic refractory wounds is quite difficult clinically. At present, people's research on this topic has gone deep into the level of cells, molecules and genes. Various growth factors can be seen clinically, such as epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), etc., and clinical trials have achieved certain results. The main reason for chronic non-healing wounds is that there are a large number of proteases including metalloproteinases in chronic non-healing wounds, which decompose endogenous growth factors secreted by wound cells and added exogenous growth factors , resulting in slowing down or stopping of wound healing; inte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K36/481A61K35/14A61P17/02A61K35/19
Inventor 霍红梅董启榕
Owner 霍红梅
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