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External traditional Chinese medicine composition for treating xerophthalmia and preparation method thereof

A composition and dry eye technology, applied in the direction of drug combination, pharmaceutical formula, hydroxyl compound active ingredients, etc., can solve the problems of corneal turbidity and aggravation that have not completely disappeared or improved, and can improve the symptoms of conjunctival congestion and corneal The effect of dyeing and prolonging the crushing time

Inactive Publication Date: 2012-02-22
北京明悦堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a general inflammatory treatment during treatment, the patient’s symptoms have not completely disappeared or improved, or even aggravated, which will lead to serious ocular surface diseases, including complications such as corneal surface abrasion, filamentous keratitis and corneal ulcer, and eventually lead to corneal opacity and serious consequences of vision loss
[0004] At present, the measures to prevent and treat dry eye are relatively limited. Mild cases can relieve symptoms by dripping "artificial tears" for a long time, but preservatives can damage the tear film; moderate cases can wear silicone eye masks, wet room mirrors, diving goggles, and therapeutic corneas. Contact lenses or implantation of punctum plugs to maintain the retention of tears in the eye; in severe cases, eyelid suture is performed to prevent the occurrence of complications such as corneal degeneration
In short, although there are many treatment methods, there are also many disadvantages, and the curative effect is not sure, and it cannot fundamentally improve the quality and quantity of the patient's own tears.

Method used

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  • External traditional Chinese medicine composition for treating xerophthalmia and preparation method thereof
  • External traditional Chinese medicine composition for treating xerophthalmia and preparation method thereof
  • External traditional Chinese medicine composition for treating xerophthalmia and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0071] Take 20g of Scutellaria baicalensis, 15g of mint, 20g of trichosanthum pollen, 10g of chrysanthemum, and 15g of Rhizoma Polygonatum, add 5 times the amount of water to extract 3 times, each time for 90 minutes, combine the extracts, filter, combine the filtrates, and set aside, take 1g of borneol, mix borneol and filtrate mix.

Embodiment 2

[0073] Take 40g of Scutellaria baicalensis, 10g of peppermint, 10g of trichosanthum pollen, 30g of sealwort, and 20g of chrysanthemum, remove impurities respectively, wash, dry, add 6 times the amount (weight times) of water to extract 3 times, each time for 120 minutes, combine the extracts, filter, and take The filtrate is concentrated into a clear ointment with a relative density of 1.15. The borneol 3g is mixed with the clear ointment, and conventional adjuvants for tablets are added to make tablets. During use, the tablets are fumigated with hot water to dissolve steam for administration.

Embodiment 3

[0075] Get 38g of Scutellaria baicalensis, 8g of peppermint, 15g of trichosanthum pollen, 35g of sealwort, and 18g of chrysanthemum, remove impurities respectively, wash, dry, add 6 times the amount (weight times) of water to extract 4 times, each time for 60 minutes, combine the extracts, filter, and take The filtrate is concentrated into a clear ointment with a relative density of 1.30. The borneol 4g is mixed with the clear ointment, and conventional auxiliary materials for pills are added to make pills. During use, the pills are fumigated with hot water and steam for administration.

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Abstract

The invention discloses an external traditional Chinese medicine composition for treating xerophthalmia and a preparation method thereof. The external traditional Chinese medicine composition for treating xerophthalmia is prepared from Baikal skullcap root, mint, radix trichosanthis, chrysanthemum flower, rhizoma polygonati and borneol. The preparation method comprises the following steps: addingwater to extract Baikal skullcap root, mint, radix trichosanthis, rhizoma polygonati and chrysanthemum flower, merging the extracting solutions, filtering, concentrating the filtrate into paste, mixing the borneol and paste, and adding conventional auxiliary materials to prepare the clinically acceptable preparation formulation. The traditional Chinese medicine composition disclosed by the invention is a pure traditional Chinese medicine external preparation, has the advantages of no toxic or side effect and quick effect taking, and can be absorbed easily; and the traditional Chinese medicinecomposition can prlong the tear break-up time, increase the tear flow, improve conjunctivitis, effectively relieve the symptoms of xerophthalmia, and the like, thereby performing the functions of xerophthalmia treatment and eye health care.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for externally treating dry eye and a preparation method thereof. Background technique [0002] With the development of society and the acceleration of the pace of life, occupational diseases represented by dry eye have become common, frequently-occurring and refractory diseases in ophthalmology. According to the survey, 13.3% of them are aged 43-84 in the United States, 17.0% in Japan, 28.7% in Canada, and 10.3% in Australia. Dry eye has many etiologies and complicated pathological process. It is a common ocular surface disease in ophthalmology clinic. The tear secretion of patients is significantly reduced or the tear composition is abnormal, the tear film breakup time is shortened, the corneal epithelium is punctate, and the fluorescein staining is positive. Since the tear film can no longer assume its ...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/12A61P27/02A61K31/045
CPCA61K31/045A61K36/287A61K36/428A61K36/534A61K36/539A61K36/8969A61P9/00A61P27/02A61K2300/00
Inventor 金明
Owner 北京明悦堂医药科技有限公司
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