Targeted human CD147 small molecule RNA interference sequence and use thereof
A technology of RNA interference and interfering sequences, applied in the field of small fragment RNA drugs, can solve the problems of cytotoxicity and unsatisfactory patient survival rate.
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[0019] The present invention is a small molecule RNA interference sequence targeting human CD147 and its application, and the small molecule RNA interference sequence targeting human CD147 is characterized in that:
[0020] Justice Chain: CGUCAGAACACAUCAACGATT
[0021] Antisense strand: UCGUUGAUGUGUUCUGACGTT.
[0022] According to the interference sequence described above, it is characterized in that it targets the human CD147 gene.
[0023] According to the interference sequence mentioned above, it is used in anti-tumor gene therapy.
[0024] The use of the small molecule RNA interference sequence targeting human CD147 inhibits proliferation, induces apoptosis, inhibits tumor invasion and metastasis, and enhances tumor drug sensitivity in human-derived tumors.
[0025] The present invention is realized in the following manner: with the CD147 gene as the target, RNAdraw and Sfold are used to analyze the possible secondary structure of CD147 and the probability of single-stra...
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Abstract
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