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Targeted human CD147 small molecule RNA interference sequence and use thereof

A technology of RNA interference and interfering sequences, applied in the field of small fragment RNA drugs, can solve the problems of cytotoxicity and unsatisfactory patient survival rate.

Inactive Publication Date: 2012-02-29
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Traditional treatment methods are mainly surgery, chemotherapy and radiotherapy. Many anticancer agents are not only toxic to cancer cells, but also to normal production cells. As a result, the survival rate of many patients is still unsatisfactory. Cervical cancer is still a major cause of death for women worldwide. disease

Method used

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  • Targeted human CD147 small molecule RNA interference sequence and use thereof
  • Targeted human CD147 small molecule RNA interference sequence and use thereof
  • Targeted human CD147 small molecule RNA interference sequence and use thereof

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Embodiment Construction

[0019] The present invention is a small molecule RNA interference sequence targeting human CD147 and its application, and the small molecule RNA interference sequence targeting human CD147 is characterized in that:

[0020] Justice Chain: CGUCAGAACACAUCAACGATT

[0021] Antisense strand: UCGUUGAUGUGUUCUGACGTT.

[0022] According to the interference sequence described above, it is characterized in that it targets the human CD147 gene.

[0023] According to the interference sequence mentioned above, it is used in anti-tumor gene therapy.

[0024] The use of the small molecule RNA interference sequence targeting human CD147 inhibits proliferation, induces apoptosis, inhibits tumor invasion and metastasis, and enhances tumor drug sensitivity in human-derived tumors.

[0025] The present invention is realized in the following manner: with the CD147 gene as the target, RNAdraw and Sfold are used to analyze the possible secondary structure of CD147 and the probability of single-stra...

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Abstract

The invention discloses a targeted human CD147 small molecule RNA interference sequence and the use thereof, which relate to small fragment RNA type medicines for restraining multiplication of cervical cancer cells, inducing cell apoptosis and enhancing chemical drug susceptibility of cells, and the use of the medicines. The interference sequence is as follows: SODN: CGUCAGAACACAUCAACGATT; and AODN: UCGUUGAUGUGUUCUGACGTT; the targeted human CD147 small molecule RNA interference sequence is used for multiplication of restraining human tumors, inducing apoptosis, restraining tumor invasion and metastasis and enhancing anti-tumor drug susceptibility.

Description

technical field [0001] The invention relates to small-segment RNA drugs for inhibiting proliferation of cervical cancer cells, inducing cell apoptosis and enhancing cell sensitivity to chemical drugs and uses thereof. Background technique [0002] RNA interference has a strong effect of inhibiting gene expression and high specificity, which has aroused widespread interest in almost all research fields in the biomedical field. RNAi technology has rapidly advanced from the laboratory to the clinic. First, the completion of the Human Genome Project made it possible to design small interfering RNA (siRNA) that can silence any gene. Second, we recognize that many new targets are inaccessible to small molecule drugs or biologics. It is therefore extremely attractive to envision a way to affect these targets at the mRNA level. [0003] RNAi technology has rapidly developed from in vitro cell and animal experiments to clinical trials in a short period of time. The first clinical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113A61K48/00A61P35/00
Inventor 张新国曾艳龙
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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