Preparation method of carboxylated polystyrene microball

A technology of polystyrene microspheres and carboxylation, which is applied in the field of preparation of carboxylated polystyrene microspheres, can solve the problem of low distribution ratio of carboxyl groups, and achieve the effect of increasing the distribution ratio

Inactive Publication Date: 2013-07-31
南京卡博生物科技有限公司
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  • Abstract
  • Description
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Problems solved by technology

However, most of the carboxyl groups of carboxylated polystyrene microspheres prepared by this method are embedded inside the microspheres, and the distribution ratio of carboxyl groups on the surface of polystyrene microspheres is not high, generally 0.25mmol / g

Method used

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Embodiment Construction

[0008] The preparation method of carboxylated polystyrene microspheres of the embodiment includes: (1) washing styrene with sodium hydroxide solution 3 times, and then washing with pure water; (2) adding carbonic acid to the washed styrene Sodium hydrogen, water and undecylenic acid form a mixed solution, and then under stirring and cooling, nitrogen gas is passed through the mixed solution for 15 minutes; (3) The mixed solution is heated to 75°C in a water bath, then potassium persulfate is added, and the reaction is carried out for 5 hours (4) Heat the mixed solution in a water bath to 82° C. and react for 3 hours, at which time carboxylated polystyrene microspheres are obtained; (5) Wash the mixed solution twice with pure water to remove impurities. In the step (2), the content of styrene is 85%, and the content of undecylenic acid is 14%. The particle size of carboxylated polystyrene microspheres obtained by this method is 150nm, and the distribution ratio of carboxyl group...

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Abstract

The invention relates to a preparation method of a carboxylated polystyrene microball. The preparation method concretely comprises the following steps: 1, cleaning styrene with a sodium hydroxide solution, and then cleaning styrene with pure water; 2, adding sodium bicarbonate, water and an olefin acid to cleaned styrene to form a mixed solution, and accessing nitrogen to the mixed solution for 10-20min with stirring and cooling; 3, heating the mixed solution to 65-80DEG C in a water bath, adding potassium peroxydisulfate, and reacting for 4-6h; 4, heating the mixed solution to 81-90DEG C in the water bath, and reacting for 2-4h; and 5, cleaning the mixed solution with pure water. The carboxyl distribution proportion on the surface of the carboxylated polystyrene microball prepared with the preparation method of the invention is high.

Description

Technical field [0001] The invention belongs to the field of microspheres for biological detection, and relates to a preparation method of carboxylated polystyrene microspheres. Background technique [0002] Carboxylated polystyrene microspheres are mainly used for cross-linking biological macromolecules for biological detection. At present, when carboxylated polystyrene microspheres are prepared by a polymerization method, carboxyl groups are introduced to the surface of the polystyrene microspheres by adding acrylic acid. However, most of the carboxyl groups of the carboxylated polystyrene microspheres prepared by this method are embedded in the interior of the microspheres, and the distribution of carboxyl groups on the surface of the polystyrene microspheres is not high, generally 0.25 mmol / g. Summary of the invention [0003] The object of the present invention is to provide a method for preparing carboxylated polystyrene microspheres, and the carboxylated polystyrene micros...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F212/08C08F220/04C08F220/64
Inventor 吕军赵世鹏
Owner 南京卡博生物科技有限公司
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