Unlock instant, AI-driven research and patent intelligence for your innovation.

Process to form a tablet and apparatus suitable for applying this process

A spherical, formulation technology, applied in the direction of making medicines into special physical or taking forms of devices, pill delivery, pharmaceutical formulations, etc., can solve problems such as fluid loss

Active Publication Date: 2015-02-18
INTERVET INT BV
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage is that a cooling-heating cycle must be performed to use this method, and the whole process is relatively slow
Furthermore, there is a risk of fluid loss from the cavity when filling with (low viscosity) fluid formulations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Process to form a tablet and apparatus suitable for applying this process
  • Process to form a tablet and apparatus suitable for applying this process
  • Process to form a tablet and apparatus suitable for applying this process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1 obtains the tablet that contains vaccine component

Embodiment 2

[0058] Embodiment 2 obtains the tablet that contains chemical drug

Embodiment 3

[0059] Example 3 Determining the Mechanical Stability of Tablets

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.

Description

[0001] general field of invention [0002] The present invention relates to a process for the preparation of rapidly disintegrating tablets containing a drug. Background of the invention [0003] Methods of preparing rapidly disintegrating tablets (also referred to in this specification as "disintegrating tablets") are known, for example, from US 5,384,124 to Farmalyoc. In a known method, a paste containing one or more drugs is formed, which is mechanically divided into cavities of defined shape and volume by dispensing the paste into cavities of predetermined shape and size. For unit doses, these cavities are present in the polyvinyl chloride carrier element. After dispensing the paste, the carrier element is placed in a lyophilizer and the paste is freeze-dried. In this way, each unit dose is formed into a tablet. The advantage of the freeze-drying method is not only to carry the drug in a very stable form, but also to obtain a solid dosage form that disintegrates on cont...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61J3/06A61K9/00A61K9/20F26B5/04
CPCA61J3/06F26B5/06A61K9/2095A61K9/0056
Inventor H·A·米德尔比克J·A·C·斯密特
Owner INTERVET INT BV