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Method for preparing propolis microcapsules and application

A technology of microcapsules and propolis, applied in the fields of application, food preparation, food science, etc., can solve the problems of reduced pharmacological activity of propolis, reduced main active ingredients and biological activities, complex components, etc., to improve human body absorption rate, improve water solubility Sexuality and wide application prospects

Active Publication Date: 2012-05-02
杭州帕特诺尔宠物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that with the prolongation of storage time, the main active components (polyphenols and flavonoids) and biological activities of propolis are significantly reduced
In addition to the main active ingredients flavonoids, propolis also contains about 10% aromatic volatile oil. Although the content of volatile oil in propolis is not high, the composition is quite complex and exerts many pharmacological activities, such as antibacterial, antifungal, etc.
However, these volatile components will slowly volatilize with the prolongation of storage time, thereby reducing the pharmacological activity of propolis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Crush and sieve 100 g of horned propolis, add 95% ethanol to stir and extract for 24 h, filter, remove the liquid by rotary evaporation, and make propolis ethanol extract. Dissolve zein in water to prepare 100 mL of 3% zein aqueous solution, adjust the pH to 10.0 with 0.1mol / L NaOH, and then adjust the solution to pH 8.0 with hydrochloric acid. Prepare pectin and gelatin at a ratio of 1:1 to prepare 100 mL of a 3% colloidal solution, and adjust the pH to 4.0 with 1 mol / L hydrochloric acid.

[0018] Add 2 g of propolis ethanol extract to 100 mL pH 8.0 aqueous solution containing 3% zein, mix thoroughly, and then slowly add 100 mL pH 4.0 3% colloidal solution. carried out above, maintaining a temperature of 40°C. After the polymerization reaction, the mixture was cooled overnight at 4°C in a refrigerator to speed up the precipitation process. The cooled mixture was frozen at -18°C and freeze-dried. The freeze-drying conditions are: condensation temperature -45°C, press...

Embodiment 2

[0023] Crush and sieve 100 g of horned propolis, add 95% ethanol to stir and extract for 24 h, filter, remove the liquid by rotary evaporation, and make propolis ethanol extract. Dissolve zein in water to prepare 100 mL of 4% zein aqueous solution, adjust the pH to 10.0 with 0.1mol / L NaOH, and then adjust the solution to pH 8.0 with hydrochloric acid. Prepare pectin and gelatin at a ratio of 1:1 to prepare 100 mL of a 6% colloidal solution, and adjust the pH to 4.0 with 1 mol / L hydrochloric acid.

[0024] Add 3 g of propolis ethanol extract to 100 ml pH 8.0 aqueous solution containing 4% zein, mix well, then slowly add 100 mL pH 4.0 6% colloid solution, this process is performed on a magnetic stirrer To proceed, keep the temperature at 35°C. After the polymerization reaction, the mixture was cooled overnight at 4°C in a refrigerator to speed up the precipitation process. The cooled mixture was frozen at -18°C, and then freeze-dried to obtain propolis microcapsules. The free...

Embodiment 3

[0029] Crush and sieve 100 g of horned propolis, add 95% ethanol to stir and extract for 24 h, filter, remove the liquid by rotary evaporation, and make propolis ethanol extract. Dissolve zein in water to prepare 100 mL of 6% zein aqueous solution, adjust the pH to 10.0 with 0.1mol / L NaOH, and then adjust the solution to pH 8.0 with hydrochloric acid. Prepare pectin and gelatin at a ratio of 1:1 to prepare 100 mL of a colloidal solution with a concentration of 8%, and adjust the pH to 4.0 with 1 mol / L hydrochloric acid.

[0030] Add 4 g of propolis ethanol extract to 100 ml pH 8.0 aqueous solution containing 6% zein, mix well, then slowly add 100 mL pH 4.0 8% colloidal solution, this process is on a magnetic stirrer To proceed, keep the temperature at 30°C. After the polymerization reaction, the mixture was cooled overnight at 4°C in a refrigerator to speed up the precipitation process. The cooled mixture was frozen at -18°C, and then freeze-dried to obtain propolis microcap...

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PUM

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Abstract

The invention provides a method for preparing propolis microcapsules. The method comprises the following steps of: preparing propolis extracting solution, preparing water-solubility corn protein, preparing colloidal solution from pectin and gelatin, performing polymerization reaction by taking the modified corn protein, the gelatin and the pectin as wall materials and alcohol-soluble propolis as core materials, and freezing and drying to prepare the propolis microcapsules. The prepared propolis microcapsules are powdered and do not contain ethanol and have peculiar smell, and the defect that propolis is difficult to dissolve in water and has peculiar smell and the defect that volatile ingredients are easy to lose are overcome, so the original active ingredients of the propolis are difficult to lose and slow in release. In the method, the wall materials do not have toxic or side effect, the pharmacological activity of the propolis is saved and exerted fully, and the double nutritional ingredients of the propolis and the corn protein are mixed together, so the method can be widely applied in fields of food, drinks, health-care food, nutritional fortified food and the like, and has abright application prospect.

Description

technical field [0001] The invention belongs to the field of deep processing of propolis raw materials, and relates to a preparation method of propolis microcapsules. technical background [0002] Propolis is a fragrant substance that bees collect plant resin and mix it with beeswax and other secretions. Propolis has a wide range of pharmacological activities, such as antibacterial, antioxidative, antiviral, anti-inflammatory, hepatoprotective and anticancer. As a functional ingredient, propolis has been widely used in food, medicine and health care products industries. At present, the world's popular products containing propolis mainly include candy, chocolate, toothpaste, scented soap and shampoo. But, because propolis is alcohol-soluble, and finished product contains very heavy taste, therefore limits the application range of propolis in food and drug field. [0003] The main active components of propolis are flavonoids, polyphenols and volatile components. The flavon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/076A23L1/30A23L2/52A23L21/20
Inventor 胡福良张翠平
Owner 杭州帕特诺尔宠物有限公司
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