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Allopurinol sustained release pellet and preparation method thereof

A technology for sustained-release pellets and allopurinol, which can be applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as high cost and complicated preparation.

Inactive Publication Date: 2012-05-09
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When cooling, the spherical particles formed due to dispersion solidify into the form of microspheres. However, with this solution, the temperature needs to be kept stable during mixing, and the preparation is more cumbersome, and professional high-temperature-resistant equipment is required, and the cost is high.

Method used

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  • Allopurinol sustained release pellet and preparation method thereof
  • Allopurinol sustained release pellet and preparation method thereof
  • Allopurinol sustained release pellet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Ball core composition:

[0015]

[0016] Prepare 1000 formulation units by the following preparation method:

[0017] (1) Ball core preparation Put allopurinol, slow-release material and hydrophobic matrix in a wet mixing granulator, spray a certain amount of water, make a soft material, extrude the soft material into a ball, and make the rounded material 70 ℃ drying, that is.

[0018] Adopt Chinese Pharmacopoeia 2010 edition two appendix XD first method to measure the release rate of this preparation, and measurement result is shown in Table 1.

Embodiment 2

[0020] Ball core composition:

[0021] Allopurinol 200g

[0022] 30g sucrose powder

[0023] Carnauba Wax 230g

[0024] Prepare 1000 formulation units by the following preparation method:

[0025] (1) Ball core preparation Put allopurinol, sustained-release material and hydrophobic matrix in a wet mixing granulator, spray a certain amount of water, make a soft material, extrude the soft material into a ball, and make the rounded material 55 ℃ drying, that is.

[0026] Adopt Chinese Pharmacopoeia 2010 edition two appendix XD first method to measure the release rate of this preparation, and measurement result is shown in Table 1.

Embodiment 3

[0028] Ball core composition:

[0029]

[0030] Prepare 1000 formulation units by the following preparation method:

[0031] (1) Ball core preparation Put allopurinol, slow-release material and hydrophobic matrix in a wet mixing granulator, spray a certain amount of water, make a soft material, extrude the soft material into a ball, and make the rounded material 75 ℃ drying, that is.

[0032] Adopt Chinese Pharmacopoeia 2010 edition two appendix XD first method to measure the release rate of this preparation, and measurement result is shown in Table 1.

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Abstract

The invention relates to an allopurinol sustained release pellet, which does not need to adopt special equipment, and comprises allopurinol, sustained release material and hydrophobicbase with the mass ratio of 1%-50%. The hydrophobicbase can adjust the drug release, concretely, after the sustained release pellet enters the body, the sustained release pellet is limited due to the entering of water, so the drug release is slowed down, and the function of retarding the drug release is played.

Description

technical field [0001] The invention relates to a novel sustained-release pellet of allopurinol. Specifically, the micropills regulate drug release through the hydrophobic matrix and sustained-release materials, and the prepared micropills have good drug release uniformity, and the micropills have a round appearance and good fluidity. Background technique [0002] Pellets refer to all kinds of pills with a diameter of less than 2.5mm, which can be made into quick-release or sustained-release pellets according to different needs. The focus of current research is on sustained-release pellets, which are made by mixing drugs and blockers or making ordinary ball cores and then wrapping controlled-release membranes. The pellets can be compressed into tablets, and the pellets can also be packed in capsules to make capsules. Sustained-release and controlled-release pellets are a new dosage form that is developing rapidly in the world. It is popular among doctors and patients for i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/519A61K47/44A61K47/14A61K47/12A61K47/10A61P19/06
Inventor 蒋海松王锦刚
Owner COSCI MED TECH CO LTD
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