Unlock instant, AI-driven research and patent intelligence for your innovation.

Pulsatile release of medicaments from a punctal plug

A pulse-type, punctal plug technology, applied in the direction of drug combination, drug delivery, pharmaceutical formulations, etc., can solve the problems of low efficiency, low concentration, and inability to obtain pharmacological effects

Inactive Publication Date: 2012-05-30
JOHNSON & JOHNSON VISION CARE INC
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Agents for eye diseases and diseases can be administered orally or by injection, but this route of administration has the disadvantage that, for oral administration, the concentration of the active agent reaching the eye is too low to obtain the desired pharmacological effect, And their use is complicated by numerous, systemic side effects, while injections pose a risk of infection
[0005] Most ophthalmic agents are currently delivered topically using eye drops which, while effective in some applications, are ineffective

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pulsatile release of medicaments from a punctal plug
  • Pulsatile release of medicaments from a punctal plug
  • Pulsatile release of medicaments from a punctal plug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The present invention includes devices and methods for forming punctal plugs that can be used to deliver an active agent to one or both of the nasolacrimal ducts and to tears, wherein the delivery of the active agent is in a pulsatile mode . The location of diffusion of the active agent is positioned to release the active agent into the tear fluid, preferably in minimal amounts into the nasolacrimal duct. The pulsatile mode is achieved by linearly aligning water-soluble encapsulated beads or other pulsatile delivery units in a carrier such as a tube, and then modulating the exposure of each pulsatile delivery unit to an aqueous solution such as tear fluid. When the first pulsatile delivery unit is exposed to an aqueous solution and dissolves, the agent encapsulated within the pulsatile delivery unit is released into the nasolacrimal duct. Dissolution of the first pulsatile delivery unit and subsequent release of the first dose of medicament then exposes the second puls...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
lengthaaaaaaaaaa
Login to View More

Abstract

This invention discloses an apparatus for providing pulsatile release of active agents via a punctal plug inserted into a punctum. A tube (101) is provided which may be inserted into a cavity of a punctal plug. One or more pulsatile delivery units (104) are arranged in a generally linear fashion within the tube. The pulsatile delivery units include a core comprising the active agent and an encapsulation layer around the core.

Description

[0001] Related Patent Applications [0002] This application for patent claims priority to U.S. Provisional Patent Application No. 12 / 857,885, filed August 17, 2010, and U.S. Provisional Patent Application No. 61 / 238,470, filed August 31, 2009, the contents of which are incorporated herein by reference basis and incorporated by reference. technical field [0003] The present invention describes methods and methods for dispensing one or more materials, such as medicaments, from a punctal plug reservoir and, in some embodiments, dispensing the drug component into the punctal plug lumen in a form that facilitates pulsatile release. equipment. Background technique [0004] In many cases, agents are administered to the eye for the treatment of eye diseases and diseases. Conventional methods for delivering agents to the eye involve topical application to the ocular surface. When properly formulated, topically administered agents can penetrate the cornea and rise to therapeutic ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/00A61K9/00
CPCA61K9/5031A61K9/0051A61M31/00A61K9/0021A61F9/00772A61F9/0026A61K9/0019A61P27/02A61F9/0008
Inventor R·B·皮尤J·M·托卡斯基B·A·科尔德伦
Owner JOHNSON & JOHNSON VISION CARE INC