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Effective fraction of Xiao Ban Xia Tang, and preparation method and application thereof

An effective part, the technology of Xiaobanxia Decoction, which is applied to the effective part of Xiaobanxia Decoction and its preparation field, can solve rare problems and achieve obvious pharmacological effects

Inactive Publication Date: 2012-07-11
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the methods and related preparations for isolating effective parts and active ingredients of drugs with good efficacy in treating vomiting from pure traditional Chinese medicine preparations are rare at present.

Method used

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  • Effective fraction of Xiao Ban Xia Tang, and preparation method and application thereof
  • Effective fraction of Xiao Ban Xia Tang, and preparation method and application thereof
  • Effective fraction of Xiao Ban Xia Tang, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Mix pinellia and ginger evenly at a weight ratio of 1:1, add 5 to 8 times the weight of water to extract for 3 to 5 hours, filter to obtain the extract, add 3 to 5 times the weight of water to the dregs, extract for 2 to 3 hours, and combine Two extracts; add ethanol to the extract until the alcohol mass content is 60-80%, let stand for 8-12 hours, centrifuge at 4500 rpm, take the supernatant, concentrate to 1-2g crude drug·mL -1 , the concentrated solution was extracted twice with diethyl ether (the amount of diethyl ether used each time was 0.8 to 1 times the volume of the concentrated solution), to obtain an ether layer and a water layer, and the water layer was adjusted to pH 7 with NaOH. After the solution was basically clarified, anion exchange Resin adsorption, and then washed with deionized water until colorless, with 0.5 ~ 1mol L -1 The resin was eluted with NaOH solution to obtain an eluent, which was adjusted to pH 3 with HCl, concentrated to dryness under re...

Embodiment 2

[0040] Embodiment 2: Detection method of organic acid components in Xiaobanxia Decoction.

[0041] 1. Instruments and reagents:

[0042] 1. Instrument

[0043]Electronic balance BP211D (Sartorius, Germany); Agilent6890 / MSD5973 system (HP, USA); MICROFUGE microcentrifuge (BACKMAN, USA).

[0044] 2. Reference substance

[0045] Succinic acid (Succinic acid, batch number 090812, Shanghai Lingfeng Chemical Reagent Co., Ltd.), hydroxysuccinic acid (Malic acid, batch number 20090328, China Huixing Biochemical Reagent Co., Ltd.), citric acid (Citric acid, batch number 081245071, Nanjing Chemical Reagent Co., Ltd.) Ltd.), linoleic acid (batch number 10129622, AlfaAesar), salicylic acid (salicylic acid, batch number 060222, Shanghai Qingxi Chemical Technology Co., Ltd.), palmitic acid (batch number 081139075, Nanjing Chemical Reagent Co., Ltd. ), phthalic acid, gallic acid, L-arginine, tartaric acid, etc., are analytically pure.

[0046] 3. Reagents

[0047] Chloroform, methanol, ...

experiment example 3

[0070] Experimental Example 3: Determination of the content of several organic acids in the organic acid part - using gas chromatography internal standard method (salicylic acid as internal standard)

[0071] 1. Instruments and reagents:

[0072] 1. Instrument

[0073] Agilent 4890 gas chromatograph, FID detector; Sartorius BP211D electronic balance.

[0074] Organic acid reference substance: succinic acid (Succinic acid, lot number 090812, Shanghai Lingfeng Chemical Reagent Co., Ltd.), hydroxysuccinic acid (Malic acid, lot number 20090328, China Huixing Biochemical Reagent Co., Ltd.), citric acid (Citric acid monohydrate, Batch number 081245071, Nanjing Chemical Reagent Co., Ltd.), linoleic acid (Linoleic acid, batch number 10129622, Alfa Aesar), salicylic acid (Salicylic acid, batch number 060222, Shanghai Qingxi Chemical Technology Co., Ltd.).

[0075] Methanol is HPLC grade, sulfuric acid, chloroform, anhydrous sodium sulfate, etc. are analytically pure, and water is sub...

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Abstract

The invention discloses an effective fraction of Xiao Ban Xia Tang. The effective fraction has physicochemical properties that: the effective fraction is a yellowish-brown extract, has certain moisture absorption and can be dissolved in hot water and ethanol; and the effective fraction mainly contains organic acid components, such as succinic acid, hydroxysuccinic acid, citric acid and linoleic acid. The invention also discloses a preparation method and application of the effective fraction of the Xiao Ban Xia Tang. An organic acid part extracted from the Xiao Ban Xia Tang has obvious pharmacological and pharmacodynamic effects. The effective fraction has an obvious effect of arresting vomiting; and through experimental models of pigeon emesis induced by both bluestone and cisplatin, results indicate that the organic acid part has obvious activity of arresting vomiting and can obviously reduce the vomiting frequency of pigeons; and the effective fraction has an effect of inhibiting gastric emptying of normal mice.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an effective part of Xiaobanxia decoction and its preparation method and application. Background technique [0002] Vomiting is a common clinical phenomenon, especially for cancer chemotherapy patients. Many patients often have to give up chemotherapy or radiotherapy due to fear of postoperative vomiting, thus delaying their illness. Although there are many drugs for treating vomiting at present, the effect is not ideal. Although drugs such as ondansetron and granisetron have certain effects on chemotherapy vomiting, these drugs are expensive and have certain side effects. It also limits their use to a certain extent. [0003] Vomiting belongs to the category of "qi inversion" in traditional Chinese medicine. It is believed that vomiting is caused by the loss of stomach harmony and the upward inversion of stomach qi. Traditional Chinese medicin...

Claims

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Application Information

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IPC IPC(8): A61K31/201A61K31/194A61P1/08
Inventor 张科卫蔡皓陈文星崔小兵吴皓
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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