Anti-osteoporosis Chinese medicinal preparation and preparation method thereof

An anti-osteoporosis, traditional Chinese medicine preparation technology, applied in traditional Chinese medicine composition and preparation, anti-osteoporosis traditional Chinese medicine preparation and preparation field, can solve the problem of deep vein thrombosis side effect and other problems, and achieve the effect of good prevention and treatment.

Active Publication Date: 2012-07-11
北京泰开尔营养科技发展有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, estrogen replacement therapy (HRT) has always been the first choice for postmenopausal osteoporosis, but its side effects in inducing reproductive system cancer and deep vein thrombosis have caused widespread controversy in the application of HRT

Method used

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  • Anti-osteoporosis Chinese medicinal preparation and preparation method thereof
  • Anti-osteoporosis Chinese medicinal preparation and preparation method thereof
  • Anti-osteoporosis Chinese medicinal preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Prepare the anti-osteoporosis preparation, the method is as follows:

[0032] (1) Take 4 kg of Epimedium, 4 kg of Pueraria Radix, and 4 kg of Dipsacus, add 70% ethanol solution 5 times their total mass, reflux extraction twice, each time for 2 hours, filter, combine the extracts, and The extract is centrifuged, and the supernatant is passed through the D312 macroporous adsorption resin column, then the macroporous adsorption resin column is quickly rinsed with water, and then eluted with 70% ethanol solution, the ethanol eluate is collected, and the eluate is recovered into ethanol Concentrate to an appropriate amount and spray dry (inlet temperature 100°C) to obtain 2.1 kg of extract;

[0033] (2) Take 1 kg of deer horn gum and 0.1 kg of oyster, ultrafinely pulverize and pass through a 100-mesh sieve to obtain 1 kg of fine powder;

[0034] (3) Mix the extract and fine powder, add appropriate amount of conventional pharmaceutical excipients (starch, cyclodextrin, etc.)...

Embodiment 2

[0036] Prepare the anti-osteoporosis granule, the method is as follows:

[0037] (1) Take 6 kg of Epimedium, 6 kg of Pueraria Radix, and 6 kg of Dipsacus, add 6 times the amount of 50% ethanol solution, reflux and extract twice, each time for 3 hours, filter, combine the extracts, centrifuge the extracts, and take The supernatant is passed through the HPD100 type macroporous adsorption resin column, then the macroporous adsorption resin column is quickly washed with water, and then eluted with 50% ethanol solution, and the ethanol eluate is collected, and the eluate is recovered to ethanol and concentrated to an appropriate amount. Spray drying (inlet temperature 100°C) to obtain the extract;

[0038] (2) Take 3 kg of deer horn glue and 0.2 kg of oyster, ultrafinely pulverize and pass through a 100-mesh sieve to obtain fine powder;

[0039] (3) Mix the extract and fine powder, add appropriate amount of conventional pharmaceutical excipients, and make tablets, granules or caps...

Embodiment 3

[0041] Prepare the capsule of anti-osteoporosis, the method is as follows:

[0042] (1) Take 5 kg of Epimedium, 5 kg of Pueraria Radix, and 5 kg of Dipsacus, add 5 times the amount of 60% ethanol solution, reflux and extract twice, each time for 2 hours, filter, combine the extracts, and centrifuge the extracts. Take the supernatant to pass through the macroporous adsorption resin column, then quickly rinse the macroporous adsorption resin column with water, then elute with 60% ethanol solution, collect the ethanol eluate, recover ethanol from the eluate and concentrate to an appropriate amount, and carry out Spray drying (inlet temperature 120°C) to obtain the extract;

[0043] (2) Take 2 kg of deer horn glue and 0.1 kg of oyster; ultrafinely pulverize and pass through a 100-mesh sieve to obtain fine powder;

[0044] (3) Mix the extract and fine powder, add appropriate amount of conventional pharmaceutical excipients, and make capsules.

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Abstract

The invention discloses an anti-osteoporosis Chinese medicinal preparation, which is prepared from the following bulk pharmaceuticals in parts by weight: 4-6 parts of epimedium herb, 4-6 parts of kudzuvine root, 4-6 parts of himalayan teasel root, 1-3 parts of deer horn gelatin and 0.1-0.2 part of oyster. The invention further discloses a preparation method of the anti-osteoporosis Chinese medicinal preparation. The method is easy to operate and implement. A formula for treating post-menopause osteoporosis is obtained according to the conventional kidney-invigorating and bone-supporting theory and the modern plant isoflavone theory. Treatment of osteoporosis with the formula is not reported relatively in the prior art. Each medicinal ingredient in the formula acts in a coordinated way and has the effects of nourishing liver and kidney and strengthening the bones and muscles, and plant isoflavone is used for replacing in-vivo insufficient female hormones, so that double effects are achieved, and good prevention and control effects on post-menopause osteoporosis are achieved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to an anti-osteoporosis traditional Chinese medicine preparation and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a metabolic bone disease, which is a systemic bone disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fracture. Postmenopausal osteoporosis is a high-incidence disease in postmenopausal women. According to foreign statistics, the risk rate of osteoporosis in women over 60 years old is 58%. Postmenopausal osteoporosis is related to the decreased level of hormones synthesized by the ovaries, resulting in bone pain and fractures, seriously affecting the quality of life of women, and increasing the disability rate and mort...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K9/16A61K9/20A61K9/48A61P19/10
Inventor 李贵海吴晓文陆永辉孙付军
Owner 北京泰开尔营养科技发展有限责任公司
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