Oral liquid formulation comprising salbutamol and guaifenesin
A technology of guaifenesin and liquid preparation, applied in the field of pharmaceutical compositions for treating cough, can solve problems such as accurate methods that do not provide stability of compositions containing salbutamol
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[0144] As an example of a preferred embodiment, a formulation is prepared using the following ingredients:
[0145] a) 80% to 98% pure water; preferably 94.7%
[0146] b) 0.001% to 0.05% salbutamol sulfate; preferably 0.025%
[0147] c) 0.1% to 2% guaifenesin; preferably 1%
[0148] d) 0.1% to 2% polymer; preferably 0.45% hydroxypropyl methylcellulose (4000cps)
[0149] e) 0.01% to 0.5% preservative; preferably 0.05% sodium methyl parahydroxybenzoate
[0150] f) 0.001% to 0.5% preservative; preferably 0.005% sodium propyl paraben
[0151] g) 0.001% to 0.1% sweetener; preferably 0.025% neotame
[0152] h) 0.1% to 1% buffer; preferably 0.3% sodium citrate
[0153] i) 0.1% to 1% buffer; preferably 0.225% citric acid
[0154] j) 1% to 5% polymer; preferably 2.5% polyvinylpyrrolidone (PVP K-90)
[0155] k) 0.01% to 1% flavoring agent; preferably 0.5% orange flavoring agent
[0156] l) 0.01% to 1% taste masking agent; preferably 0.2% taste masking agent
[0157] The formulation is prepared using the...
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