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Method for removing cefaclor impurities

A cefaclor impurity, cefaclor technology, applied in the direction of organic chemistry, can solve the problems of slow dissolution, difficult to remove impurities, easy to cause allergic reactions, etc., to achieve the effect of reducing allergic reactions and reducing the incidence rate

Inactive Publication Date: 2020-04-24
广州维奥康药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Cefaclor is mainly synthesized by enzymatic method in pure water solvent at present, but, in practical application, it is found that the cefaclor produced by this preparation method often contains a small part of impurities that are difficult to remove, because cephalosporin Clorox is insoluble in water, resulting in slow dissolution in the organism. If there are more impurities, it will eventually affect the bioavailability of the product and easily cause allergic reactions

Method used

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  • Method for removing cefaclor impurities
  • Method for removing cefaclor impurities
  • Method for removing cefaclor impurities

Examples

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Embodiment 1

[0041] like figure 2 As shown, in this embodiment, the complex of 100g cefaclor is weighed, and the complex is put into 500ml of butyl fat solvent to dissolve and form a suspension, wherein the temperature of the butyl fat solvent is at 18-22°C, By stirring the suspension, the pH value of the suspension is adjusted to 0.8, so that the impurities are precipitated, and then by filtration, the impurities that are not dissolved in the butyl solvent are removed, and the filtered organic solvent is extracted to extract the cephalosporin containing Crowe's Organic Solvent.

[0042] After putting in the activated carbon, adjust the pH value of the organic solvent to 3.8-4.2 by adding an alkaline reagent, wait for 1 hour for the substance to precipitate, and adjust the temperature of the organic solvent to 30°C, and perform secondary filtration. In the application, it can be filtered while stirring, so that the precipitate can be filtered better, and the filtered material can be put ...

Embodiment 2

[0050] like image 3 As shown, in the present embodiment, the complex of 100g cefaclor is weighed, and the complex is put into a butyl fat solvent to dissolve and form a suspension. By stirring the suspension, the pH value of the suspension is adjusted to 1.5, The impurities are separated out, and then the impurities insoluble in the butyl fat solvent are removed by filtration, and the filtered organic solvent is extracted to extract the organic solvent containing cefaclor.

[0051]After putting in the asbestos fiber, adjust the pH value of the organic solvent to 3.8-4.2 by adding an alkaline reagent, wait for 1 hour for the substance to precipitate, and adjust the temperature of the organic solvent to 35°C, perform secondary filtration, and In practical application, it is possible to filter while stirring, so that the precipitate can be filtered better, and the filtered material is put into a mixture of methanol, ethanol, acetone and water, wherein the low-carbon solvent and ...

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Abstract

The invention relates to the field of medicine purification, and in particular, relates to a cefaclor impurity removal method which comprises the following steps: S1, weighing a cefaclor compound, anddissolving the compound in an organic solvent; S2, filtering and separating the organic solvent, and extracting the organic solvent containing cefaclor; S3, adjusting the acid-base value of the organic solvent and adjusting the temperature of the organic solvent, and performing secondary filtration by utilizing an adsorbate; S4, putting the adsorbate into a mixed solution of a low-carbon solventand water, and crystallizing cefaclor adsorbed on the adsorbate. According to the cefaclor impurity removal method, cefaclor impurities are put in the organic solvent for dissolving, cefaclor insoluble in water can be dissolved in the organic solvent, the organic solvent of cefaclor is separated, filtered and extracted, the pH value is controlled, cefaclor particles with low impurity content are obtained, and the occurrence rate of allergic reaction possibly caused by excessive impurities of medicines is reduced.

Description

technical field [0001] The invention relates to the field of medicine purification, in particular to a cefaclor impurity removal method. Background technique [0002] Cefaclor belongs to the second generation of oral cephalosporins. It mainly binds to the penicillin-binding protein in bacterial cells and inhibits the biosynthesis of bacterial cell walls to play a bactericidal effect. It has high efficiency, broad spectrum, and good chemical stability. At present, it is one of the important drugs for clinical treatment of bacterial infection. [0003] Cefaclor is mainly synthesized by enzymatic method in pure water solvent at present, but, in practical application, it is found that the cefaclor produced by this preparation method often contains a small part of impurities that are difficult to remove, because cephalosporin Clorox is insoluble in water, resulting in slow dissolution in the organism. If there are more impurities, it will eventually affect the bioavailability of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/59C07D501/12
CPCC07D501/59C07D501/12
Inventor 彭贵子周建忠张毅俊
Owner 广州维奥康药业科技有限公司
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