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Resveratrol and spirulina composition and preparations and preparation method thereof

A technology of resveratrol and composition, applied in the field of pharmaceutical preparations, can solve the problem that undisclosed spirulina and resveratrol composition prevent or treat diabetic complications, and there is no good health care medicine or preventive medicine for diabetic complications and other problems, to achieve the effect of improving stability and bioavailability, reducing blood viscosity and capillary fragility, and protecting the liver

Active Publication Date: 2013-10-16
甘肃凯源生物技术开发中心有限责任公司 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, it is disclosed that resveratrol and spirulina are mixed with other substances respectively for the treatment of diabetes. The application of veratrol in the treatment of diabetic nephropathy; But the report that Spirulina and resveratrol composition is used for preventing or treating diabetic complication has not yet been disclosed in the prior art
At present, there are many drugs for treating diabetes, but there are no good health care or preventive drugs for diabetic complications

Method used

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  • Resveratrol and spirulina composition and preparations and preparation method thereof
  • Resveratrol and spirulina composition and preparations and preparation method thereof
  • Resveratrol and spirulina composition and preparations and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation:

[0045] 1) Preparation of high-purity resveratrol: Dried peanut red coat and pulverized it, carried out supercritical carbon dioxide extraction on crushed peanut red coat, used absolute ethanol and propanol as entraining agents, peanut red coat, entrainer, The mass ratio of the circulating amount of carbon dioxide per hour is 1:0.1:20, the pressure of the extraction tank is 10Mpa, the temperature is 50°C, the pressure of the separation tank is 5Mpa, the temperature is 20°C, the extraction time is 3h, the extract is collected, concentrated, and the Put the concentrate on a macroporous resin adsorption column, elute with 30% ethanol, collect the eluate, concentrate and dry to obtain high-purity resveratrol with a purity of 95%;

[0046] 2) Spirulina is crushed, mixed evenly with high-purity resveratrol, and passed through a 50-mesh sieve to obtain a resveratrol-spirulina composition.

Embodiment 2

[0049] Preparation:

[0050] 1) Preparation of high-purity resveratrol: crush grape seed pomace, add 90% ethanol to reflux and extract for 3 times, the amount of ethanol added for the first time is 5 times that of grape seed pomace, reflux for 5 hours, and add The amount of ethanol is 6 times that of grape seed pomace, reflux for 2 hours, the amount of ethanol added for the third time is 1 times that of grape seed pomace, reflux for 3 hours, combine the reflux liquid, filter, and concentrate the filtrate until the temperature is 70 °C and the relative density is The thick paste of 1.30 was dried to obtain the grape seed pomace extract; the grape seed pomace extract was dissolved in 1% aqueous sodium bicarbonate solution, stirred for 50 min, and the precipitate was separated, washed with water until neutral, and then The precipitate was added to 10 times the amount of water, dissolved at 90°C, the aqueous solution was slowly cooled to 25°C, left to stand, the precipitate...

Embodiment 3

[0056] Preparation:

[0057] 1) Preparation of high-purity resveratrol: Dissolve 0.01mol of 3,5-dimethoxybenzaldehyde and 0.01mol of p-methoxyphenylacetonitrile in 10ml of ethanol, add 0.02mol of sodium metal, and heat at 75°C Reflux for 12 hours, cool, and precipitate crystals to obtain 3,4', 5-trimethoxystilbene nitrile. Dissolve 3,4', 5-trimethoxystilbene nitrile in ethylene glycol, add hydroxide Sodium 0.3mol, stir, react at 130°C, then add dilute hydrochloric acid to acidify, and hydrolyze to obtain 3,4', 5-trimethoxystilbene acid, under the catalysis of Cu, in quinoline at 200 decarboxylation reaction at ℃ to obtain trans-3,4',5-trimethoxystilbene, under the catalysis of boron tribromide, demethylation reaction at 30 ℃ to obtain resveratrol with a purity of 99% alcohol;

[0058] 2) Preparation of Astragalus extract: crush Scutellaria baicalensis, add water and decoct three times, the first water consumption is 10 times the weight of Astragalus, decocting for 3 h...

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Abstract

The invention relates to a resveratrol and spirulina composition and preparations and a preparation method thereof. The composition comprises spirulina and high-purity resveratrol with the purity higher than 80%; the composition further comprises an astragalus root extract, a tartary buckwheat extract and vitamin C; and a solid preparation is prepared from the composition and adjuvants, wherein the adjuvants comprise hydroxymethyl cellulose, microcrystalline cellulose and beta-cyclodextrin, and the beta-cyclodextrin can be used for improving the solubility and stability of the composition and improving the bioavailability of the solid preparation. The solid preparation disclosed by the invention can be used for promoting the recovery of islet cells, improving glucose tolerance, lowering blood viscosity and the brittleness of capillaries, promoting blood circulation, lowering blood sugar and blood fat and protecting the liver, and has a very good treatment effect on the prevention or treatment of diabetes, complications of diabetes and cardio-cerebral vascular diseases.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a resveratrol spirulina composition and its preparation and preparation method. Background technique [0002] Diabetes is a common disease. According to statistics, about 50% of diabetics are combined with hyperlipidemia and other senile diseases. Diabetes and its related complications have become a considerable public health problem. [0003] Resveratrol, also known as stilbene triphenols, chemically named (E)-3,4',5-trihydroxystilbene, is a natural polyphenol with strong biological properties, mainly derived from grapes Seed dregs, knotweed, peanuts and other plants are white needle-like crystals that are easily soluble in organic solvents such as ethanol and acetone; resveratrol is also a natural antioxidant that can reduce blood viscosity and inhibit platelet aggregation and vasodilation, keep the blood flowing, have the functions of delaying aging, regulating bloo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K36/70A61K47/48A61K9/48A61K9/20A61P3/10A61P9/00A61P9/12A61P9/10A61K31/05A61K31/375A61K35/748A61K47/69
Inventor 罗光宏祖廷勋杨生辉王丹霞
Owner 甘肃凯源生物技术开发中心有限责任公司
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