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Method for detecting chlorphenamine maleate content in Chinese-western compound preparation

A technology of chlorpheniramine acid and compound preparations, which is applied in the field of medicine, can solve the problems of unfavorable drug safety and small safe dose range, and achieve the effects of strong practicability, small detection error and good reproducibility

Inactive Publication Date: 2006-11-22
蔡炜
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

The safe dose range of chlorpheniramine maleate is small, if its content in the preparation cannot be effectively controlled, it will be unfavorable for drug safety

Method used

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  • Method for detecting chlorphenamine maleate content in Chinese-western compound preparation
  • Method for detecting chlorphenamine maleate content in Chinese-western compound preparation
  • Method for detecting chlorphenamine maleate content in Chinese-western compound preparation

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Embodiment Construction

[0014] 1. Use octadecylsilane bonded silica gel as the filler; use 0.02mol / L sodium acetate solution [each 100ml buffered saline solution contains 0.5ml of triethylamine]-acetonitrile (73:27) as the mobile phase, adjust the pH to 3 with acetic acid .4; detection wavelength is 264nm. Take a sample and weigh it accurately (approximately equivalent to 5 mg of chlorpheniramine maleate), extract with methanol-chloroform (5:95) mixed solvent under continuous reflux for 8 hours, put the extract on a water bath and evaporate to dryness, and wash the residue with methanol Dissolve, transfer to a 100ml measuring bottle, add methanol to the mark, shake well, filter, accurately measure 10 μl of the subsequent filtrate, inject it into the liquid chromatograph, and record the chromatogram; take an appropriate amount of chlorpheniramine maleate reference substance, and accurately weigh Determined, determined with the same method, calculated by the peak area according to the external standard...

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Abstract

The disclosed detection method for Chlorphenamine Maleate content in preparation comprises: with HPLC, using mixed solvent with alcohol and weak-polar organic solution as extraction solution, octadecylsilicane chemically bonded silica as filler, and the mobile phase with brine, aminoethane and acetonitrile. This invention is simple and has well detection effect.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and relates to a method for detecting the content of chlorpheniramine maleate in compound preparations of Chinese and western medicines by using high performance liquid chromatography. Background technique [0002] Chlorpheniramine maleate is an antihistamine agent, which is widely used in combination with traditional Chinese medicine to form compound preparations to treat acute and chronic bronchitis, bronchial asthma, headache and body pain caused by various colds and upper respiratory tract infections, nasal congestion, runny nose, Cough, sore throat and other related symptoms, such as Gansukang Capsules, Gansukang Tablets, Keteling Capsules, Vc Yinqiao Tablets, Ganmaoqing Tablets, etc. The methods for determining the content of chlorpheniramine maleate include ultraviolet spectrophotometry, thin-layer scanning, flow injection chemiluminescence, and high-performance liquid chromatography. Be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02B01D11/02
Inventor 蔡炜蒋蔷罗语菁
Owner 蔡炜
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