Compound amino acid dipeptide injection as well as preparation method and application thereof
A compound amino acid and injection technology, applied in the field of biomedicine, can solve problems such as inability to adapt to patient material energy metabolism, easy oxidation of amino acids, malignant laryngeal edema, etc., to reduce risks and the probability of allergic reactions, and damage liver and kidney Function, intestinal protection effect
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Embodiment 1~6
[0037] 1. Prescription: the prescription of embodiment 1~6 is as shown in table 1 below:
[0038] Table 1
[0039]
[0040]
[0041] 2. Preparation method
[0042] According to the prescription ratio of Examples 1-6, the above-mentioned components are added one by one in the water for injection at 40-95 °C deoxygenated in advance, and then in N 2 Stir under protection until the components of the drug are completely dissolved, and control the dissolved O in the liquid. 2 The concentration should not be higher than 1ppm, and then add the above liquids respectively to the pre-vacuumized and filled with N 2 In a three-chamber packaging bag, add water to the volume and then seal it. Among them, based on a total of 1000mL, the three chambers are respectively filled with 100-925mL of branched-chain amino acid solution and 25mL of L-alanyl-L-glutamine solution. ~400mL and 0~500mL mixed solution containing arginine hydrochloride and vitamin B6; and the pH values of the three...
experiment example
[0053] 1. Stability experiment
[0054] Taking Example 1 and Comparative Example 1, and Example 6 and Comparative Example 6 as examples respectively, the prepared injection was stored in a cool and dark place for 0 to 6 months. The experimental results are shown in Tables 3 and 4 below:
[0055] Table 3 embodiment 1 and comparative example 1 injection stability experiment
[0056]
[0057]
[0058] It can be seen that the stability of Example 1 and Comparative Example 1 all meet the requirements, and the stability of Example 1 is better.
[0059] Table 4 embodiment 6 and comparative example 6 injection stability experiment
[0060]
[0061]
[0062] It can be seen that the stability of Example 6 and Comparative Example 6 all meet the requirements, and the stability of Example 6 is better.
[0063] 2. Vascular irritation test
[0064] Vascular irritation test result shows, embodiment 1,6, comparative example 1 rabbit's marginal ear vein test experiment shows that...
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