Contrast agent for photoacoustic imaging and photoacoustic imaging method utilizing same

A photoacoustic imaging and contrast agent technology, which can be applied to preparations for in vivo experiments, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., which can solve the problem of low sensitivity of contrast media and low absorption coefficient of contrast media and other problems to achieve the effect of high antigen binding performance

Active Publication Date: 2012-07-11
CANON KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this photoacoustic imaging has a problem of low sensitivity to the contrast agent for photoacoustic imaging, that is, the absorption coefficient per molecule of the contrast agent is low

Method used

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  • Contrast agent for photoacoustic imaging and photoacoustic imaging method utilizing same
  • Contrast agent for photoacoustic imaging and photoacoustic imaging method utilizing same
  • Contrast agent for photoacoustic imaging and photoacoustic imaging method utilizing same

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Embodiment approach

[0084] Hereinafter, embodiments of the present invention will be described with reference to the drawings and the like. These embodiments individually disclose examples of the contrast agent for photoacoustic imaging of the present invention and photoacoustic imaging using the contrast agent. The technical scope of the present invention is not limited to them.

no. 1 Embodiment approach

[0086] The contrast agent for photoacoustic imaging according to the first embodiment is represented by Formula 1, and includes: particles containing iron oxide particles that absorb light in the near-infrared region; and at least one or more particles immobilized on the particles containing iron oxide particles. The ligand molecule, wherein the ligand molecule is immobilized at a density equal to or greater than the cell surface density of the target molecule.

[0087] MNP-((L) l -(P) m ) n (Formula 1), wherein MNP represents a particle containing iron oxide particles; L represents a linker molecule; P represents a ligand molecule; l represents 0 or 1; and m and n represent integers of 1 or greater.

[0088] The contrast agent for photoacoustic imaging of the present embodiment has been realized by paying attention to the high absorption coefficient in the near-infrared region of the particles containing iron oxide particles. The contrast agent is characterized in that: th...

no. 2 Embodiment approach

[0142] (iron oxide particle-containing particle with HER2-binding single-chain antibody)

[0143] The second embodiment of the present invention includes a compound represented by Formula 2, which has: particles containing iron oxide particles; and at least one or more epidermal growth factor receptor 2 (HER2)-binding single-chain antibody (scFv).

[0144] MNP-(-(L) l -(P) m ) n (Formula 2), wherein MNP represents particles containing iron oxide particles; L represents linker molecules; P represents epidermal growth factor receptor 2 (HER2)-binding single-chain antibody (scFv); l represents 0 or 1; and m and n Represents an integer of 1 or greater.

[0145]The compounds can be used as contrast agents for photoacoustic imaging according to the invention and as contrast agents for magnetic resonance imaging (MRI). In addition, compounds with ferromagnetic or paramagnetic particles containing iron oxide particles can be used for magnetic separation or purification of HER2 by ...

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Abstract

Disclosed is a novel contrast agent for photoacoustic imaging that has a high ability to bind with a target molecule and that transmits a high photoacoustic signal. The contrast agent for photoacoustic imaging represented by formula 1 is characterized by containing particles containing iron oxide particles that absorb light in the near-infrared region and at least one ligand molecule attached to the aforementioned particles containing iron oxide particles, and by the attachment density of the aforementioned ligand molecule being at least the cell surface density of the target molecule. MNP-((L)l-(P)m)n (formula 1) (In the formula, MNP is a particle containing an iron oxide particle, L is a linker molecule, P is a ligand molecule, l is 0 or 1, and m and n are integers that are greater than or equal to 1.)

Description

【Technical field】 [0001] The present invention relates to a contrast agent for photoacoustic imaging and a photoacoustic imaging method using the contrast agent for photoacoustic imaging. 【Background technique】 [0002] Photoacoustic imaging has been reported in recent years as an optical diagnostic imaging method. This method uses the property of ultrasound to scatter less in vivo (in a sample) than light, and to image the in vivo density distribution of absorbed light energy with high resolution. In particular, the method involves: irradiating a living body with pulsed light; detecting signals of acoustic waves (ultrasonic waves) formed from biological tissues absorbing the energy of the pulsed light propagated / diffused in the body; and analyzing these signals to obtain the absorbed light energy. In vivo density distribution. Photoacoustic imaging is a convenient and non-invasive diagnostic method. However, due to light scattering and absorption in biological tissues, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K41/00A61K49/226A61K47/48584A61K49/225A61K47/6855Y10T428/2982
Inventor 山内文生小河贤史金崎健吾井上幸子福井树南昌人岸麻裕子
Owner CANON KK
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