Antiarrhythmic medicinal composition and preparation method thereof

A composition and drug technology, applied in the direction of drug combination, medical formula, cardiovascular system diseases, etc., can solve the problems of body irritation, avoid drug hydrolysis, improve the area under the drug time curve, improve drug dissolution and The effect of the degree of absorption
CN102579421AInactive Publication Date: 2012-07-18JILIN BODA PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JILIN BODA PHARMA
Publication Date
2012-07-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an antiarrhythmic medicinal composition and a preparation method thereof. According to the composition, active ingredients comprise dronedarone or pharmaceutically-acceptable salt thereof, and non-active ingredients comprise one or more of polymers and multiple common additives of preparations. The preparation process for the composition comprises the key step of preparing solid dispersoid by a hot-melting extrusion method, so that tablets, capsules and granules can be prepared. The invention has the advantages that: a preparation with a high dissolution rate can be prepared according to a proper formula by a simple and pollution-free process, and the preparation can be absorbed well in bodies; and samples are stable under the condition of accelerated tests.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an antiarrhythmic drug composition and a preparation method thereof. Background technique

[0002] In the field of treating arrhythmia, amiodarone is one of the most effective drugs, but long-term use of amiodarone has many adverse reactions, among which thyroid, retinal damage and pulmonary toxicity are the main ones. The above adverse reactions and the iodine in its structure close relationship. Dronedarone is a benzofuran derivative. It has a chemical structure similar to amiodarone without iodine. It has minimal effect on thyroid hormones. Its lipophilicity is weaker than that of amiodarone, and phospholipids will not be deposited in the lungs after taking it. , so adverse reactions outside the cardiovascular system are less than amiodarone. In addition, dronedarone has blocking effects on calcium, potassium, and sodium channels, and has anti-adrenergi...

Claims

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