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Caulis Spatholobi extract, application thereof and new application of isoliquiritigenin

A kind of technology of isoliquiritigenin and Caulis Spatholobus, applied in the direction of drug combination, medical preparations containing active ingredients, organic active ingredients, etc.

Active Publication Date: 2012-07-18
陈建萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that the incidence of triple-negative breast cancer in African-American women is about twice that of white women. The proportion of triple-negative breast cancer reported in South Korea is 14.7%, and Japan is 15%. There is no multi-center, large-sample correlation in China. Research data reported, but there are reports that the proportion should be lower than that of blacks and higher than that of whites

Method used

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  • Caulis Spatholobi extract, application thereof and new application of isoliquiritigenin
  • Caulis Spatholobi extract, application thereof and new application of isoliquiritigenin
  • Caulis Spatholobi extract, application thereof and new application of isoliquiritigenin

Examples

Experimental program
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Effect test

Embodiment 1

[0107] 100 g of Millet Spatholobus medicinal material coarse powder was decocted and extracted twice with 10 times of water (W / V), 1 hour each time, the two extracts were combined, concentrated to dryness under reduced pressure, and 9.7 g of Milletera Spatholobus aqueous extract was obtained. The water extract is added with conventional excipients to make granules according to the conventional process.

Embodiment 2

[0109] Millet Spatholobus medicinal material coarse powder 100g, reflux extraction 2 times with 10 times the amount (W / V) of 60% ethanol, each time 1 hour, combine two extracts, concentrate under reduced pressure to dryness, obtain Millet Spatholobus 60% Alcoholic extract 15.5g. The alcohol extract is added with conventional auxiliary materials to make drop pills according to the conventional process.

Embodiment 3

[0111] 1000g of the coarse powder of Spatholobus Spatholobus, ultrasonically extract 2 times with 10 times the amount (W / V) of 60% ethanol, each time for 1 hour, combine the two extracts, concentrate under reduced pressure until there is no alcohol smell, then use petroleum ether respectively , ethyl acetate, and n-butanol were sequentially extracted to obtain 4 extracts with different polarities: petroleum ether extract (PE) 1.1g, ethyl acetate extract (ETOAC) 11.5g, n-butanol extract-I ( BUOH-I) 24.4g and the water layer residue (DW) 79.3g.

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Abstract

The invention provides Caulis Spatholobi extract, an application thereof and a new application of isoliquiritigenin, and particularly provides Caulis Spatholobi extract containing isoliquiritigenin, an active part and a monomer compound isoliquiritigenin as well as an application of a composition in preparing medicine for treating and preventing triple-negative breast cancer. The composition consists of isoliquiritigenin and one or more active ingredients in gallocatechin, epicatechin and catechin.

Description

technical field [0001] The present invention relates to the new application of the extract of Milletia spatholobus and isoliquiritigenin, in particular to the application of the extract of Milletera spatholobus and isoliquiritigenin containing isoliquiritigenin in the preparation of medicines for preventing and treating triple-negative breast cancer. Background technique [0002] Spatholobus spatholobus is the dried cane of the plant Spatholobus suberectus Dunn in the family Leguminosae. It is the effect of nourishing blood and promoting blood circulation discovered after the Song Dynasty. In recent years, there have been a small number of literature reports that this drug has anti-tumor effect. We have carried out systematic research on this drug. [0003] In recent years, studies have found that Spatholobus and its extracts have anti-tumor activity, but there is no report on breast cancer, especially triple-negative breast cancer (this special type of breast cancer). [0...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61K31/12A61P35/00A61P15/14
Inventor 陈建萍王志宇王冬梅杨得坡郑骁王能
Owner 陈建萍
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