Medicinal composition for treating rheumatoid arthritis, and preparation method and application thereof

A rheumatoid and composition technology, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., to achieve significant therapeutic effects, low toxic and side effects, and good analgesic effects.

Inactive Publication Date: 2012-07-18
SICHUAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no relevant report on the treatment of rheumatoid arthritis with the combination of Heiguteng, Gentiana chinensis and Yuanhu

Method used

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  • Medicinal composition for treating rheumatoid arthritis, and preparation method and application thereof
  • Medicinal composition for treating rheumatoid arthritis, and preparation method and application thereof
  • Medicinal composition for treating rheumatoid arthritis, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The preparation of embodiment 1 pharmaceutical composition capsule of the present invention

[0044] Take 25g of Rhizoma chinensis, 10g of Gentiana chinensis, and 10g of Rhizoma chinensis, respectively crush them through a 60-mesh sieve, extract them twice with 50% ethanol at a material-to-liquid ratio of 1:8, and reflux in a water bath at 60°C for 2 hours each time. The extract was centrifuged at high speed in a centrifuge (centrifugation conditions: 3600r / min, 10-15°C, 10min), the supernatant was transferred to a round bottom flask, and dried under reduced pressure with a rotary evaporator (drying conditions were -0.085MPa, 50°C) Recover the solvent to a thick liquid extract, dry it in a vacuum drying oven (drying condition: -0.05MPa, 60°C, 24h), add an appropriate amount of microcrystalline cellulose, pulverize, and mix well to prepare capsules.

Embodiment 2

[0045] The preparation of embodiment 2 pharmaceutical composition granules of the present invention

[0046]Take 100g of Helicopteris chinensis, 10g of Gentiana chinensis, and 10g of Rhizoma chinensis, crush them through a 40-mesh sieve, add 20 times the weight of 50% ethanol, power 800W, ultrasonic interval time 8s / 2s, temperature 50°C, extract twice, 30min each time . Combine the extracts, filter, and recover the solvent from the filtrate under reduced pressure until it becomes a thick liquid extract, add an appropriate amount of dextrin, and granulate to obtain the granules of the present invention.

Embodiment 3

[0047] Embodiment 3 The preparation of pharmaceutical composition oral liquid of the present invention

[0048] Take 25g of S. chinensis, 40g of Gentiana chinensis, and 40g of Rhizoma chinensis, respectively crush them through an 80-mesh sieve, add 10 times of 50% ethanol and impregnate for 48 hours, then percolate, collect the percolation liquid, and continue percolating with an appropriate amount of 50% ethanol until it reaches the wetness. Until the liquid is colorless or slightly yellow, the filtrates are combined and filtered, and after the filtrate is decompressed to recover ethanol, add a preservative and an appropriate amount of stevioside, and stir well to obtain the oral liquid of the present invention.

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Abstract

The invention discloses a medicinal composition for treating rheumatoid arthritis. The medicinal composition is prepared from the following Chinese herbal medicines in part by weight: 2.5 to 10 parts of periploca forrestii schltr, 1 to 4 parts of gentiana macrophylla and 1 to 4 parts of yanhusuo. The invention also discloses a preparation method and a quality detection method for the medicinal composition, and application of the medicinal composition. Through reasonable compatibility of the periploca forrestii schltr, the gentiana macrophylla and the yanhusuo, the medicinal composition has an obvious curative effect on arthritis induced by a complete freund adjuvant, good anti-inflammatory and analgesic effects, a better pharmaceutical effect compared with the simple medicinal material and the medicine which is prepared from other Chinese herbal medicines, and small toxic and side effects and achieves a synergistic effect. The modern pharmological study proves that the medicinal composition can safely and effectively treat rheumatoid arthritis and provides a new choice for clinical treatment.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating rheumatoid arthritis, a preparation method and application thereof. Belongs to the field of medicine. Background technique [0002] Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with unknown etiology. Currently, it is recognized that rheumatoid arthritis is an autoimmune disease with a high disability rate after 2 to 3 years of onset. There are at least 4 million patients in our country. It may be related to differences in endocrine, metabolism, nutrition, geography, occupation, psychological and social environments, bacterial and viral infections, and genetic factors. [0003] Rheumatoid arthritis belongs to the category of arthralgia syndrome in traditional Chinese medicine. Physicians in the past dynasties called it calendar festival, crane knee wind, stubborn arthralgia, muscle arthralgia, bone arthralgia, kidney arthralgia, etc. The internal cause is weakn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66G01N30/02A61P19/02A61P29/00
Inventor 张宏胡晓荣张晓喻刘刚
Owner SICHUAN NORMAL UNIVERSITY
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