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Application of ginkgolic acid in treating arthritis

A technology of ginkgolic acid and arthritis, which is applied in the field of biomedicine, and can solve the problem of ginkgolic acid arthritis and gastrointestinal tract reactions such as narciscine, non-steroidal anti-inflammatory drugs, glucocorticoids or adrenal corticosteroids, etc. Liver and kidney problems, achieve the effect of improving joint swelling, reducing joint damage, and inhibiting local inflammation

Inactive Publication Date: 2012-08-22
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the treatment of gout, anti-inflammatory and analgesic (colchicine, non-steroidal anti-inflammatory drugs, glucocorticoids or adrenal corticosteroids, etc.), blood uric acid-lowering (sulfonyl compounds probenecid, besulfazone, etc.) , allopurinol, etc.), but such drugs have obvious gastrointestinal reactions and liver and kidney side effects after long-term use, and are prone to relapse after drug withdrawal
There is no report on the use of ginkgolic acid in the treatment of arthritis

Method used

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  • Application of ginkgolic acid in treating arthritis
  • Application of ginkgolic acid in treating arthritis
  • Application of ginkgolic acid in treating arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The extraction process of ginkgolic acid from the ginkgo fruit outer testa is as follows: the ginkgo fruit outer testa is peeled off, dried in the sun, and pulverized with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, and extract for 4 hours each time , (Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain ginkgolic acid extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water; weighed, and determined the content of ginkgolic acid (mg / g).

...

Embodiment 2

[0031]The extraction process of ginkgo phenolic acid from ginkgo fruit ginkgo is as follows: peel the ginkgo fruit, put it into a tissue grinder, and pulverize it. Accurately weigh a certain amount of pulverized Ginkgo fruit, add 80% ethanol with a solid-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60° C., each extraction time is 4 hours, (Note : After adding liquid, the mouth of the beaker is sealed with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0032] Gi...

Embodiment 3

[0036] The extraction process of ginkgophenolic acid in ginkgo leaves is as follows: cut the ginkgo leaves into pieces, put them into a pulverizer and pulverize them. Accurately take a certain amount of crushed Ginkgo biloba, add 80% ethanol with a solid-liquid ratio of 1:6 (W / V), and stir and extract 2 times at a water bath temperature of 60° C., each extraction time is 4 hours, ( Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0037] Ginkgo...

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Abstract

The invention relates to the application of ginkgolic acid in treating arthritis. The ginkgolic acid comprises ginkgoic acid, ginkgol, ginkgoic diphenol and the like and can be obtained from the extracts of the parts of the leaves, the fruits, the episperms, the rhizomes and the like of gingkoes by a chemical separation method. The arthritis is rheumatoid arthritis, chronic infectious arthritis, gouty arthritis, osteoarthritis and the like. A medicine, a medical appliance or a disinfector preparation which contains the ginkgolic acid and is used for treating the arthritis contains 0.001 to 80 percent of ginkgolic acid (calculated according to weight percent) and an external preparation substrate or an acceptable carrier which is generally used pharmaceutically; and the preparation is any external preparation formulation which is given pharmaceutically. The research of a pharmacological experiment shows that the ginkgolic acid has the favorable actions of improving arthrocele, relieving joint injury and suppressing local inflammation to an animal model with the arthritis. Clinical trial shows that the ginkgolic acid has an obvious therapeutic action to each type of arthritis, and the effective rate reaches more than 90 percent. In use, the ginkgolic acid is safe and has no side effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of ginkgolic acid in preparing preparations for treating arthritis. Background technique [0002] There are many types of arthritis, such as rheumatoid arthritis, rheumatoid arthritis, gouty arthritis, osteoarthritis, ankylosing arthritis, ankylosing spondylitis, reactive arthritis, tendonitis, bursitis, shoulder Zhou Yan, etc., the first four are the most common clinically. [0003] Rheumatoid arthritis is a chronic, progressive, systemic autoimmune disease characterized by symmetric polyarthritis. , cartilage and subchondral bone destruction. The clinical manifestations are mainly symmetry, pain, stiffness, swelling, deformation and functional decline of multiple joints and small joints. In the early stage, joint redness, swelling, heat, pain and dysfunction appear. The lesions are persistent and recurrent, and then cause joint cartilage and Destructi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/60A61K31/05A61P19/02A61P29/00A01N37/40A01N31/16A01N31/08A01P1/00
Inventor 王青雷红
Owner 王青
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