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Smilax extract, and preparation method and application thereof

A technology of extract and sarsaparilla, which is applied to the extraction of active extracts containing total saponins. The field of preparation of this active extract can solve the problems of limited clinical application and market scale, low extraction rate of active ingredients, large dosage, etc. problem, to achieve the effect of easy industrial promotion and application, simple and easy preparation method, and abundant sources

Inactive Publication Date: 2012-09-19
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing sarsaparilla preparations are all prepared from sarsaparilla medicinal materials through water decoction and alcohol precipitation process, which has the disadvantages of low extraction rate of active ingredients and large dosage, which limits the clinical application and market scale of the drug

Method used

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  • Smilax extract, and preparation method and application thereof
  • Smilax extract, and preparation method and application thereof
  • Smilax extract, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This example is used to illustrate the preparation method of the sarsaparilla rhizome extract of the present invention.

[0032] (1) Get 5.0 kg of sarsaparilla rhizome (purchased from Henan Anguo Medicinal Materials Wholesale Market, place of origin Hubei), heat and reflux extract with 60 volume % ethanol for 3 times (respectively extract 2 hours, 1 hour and 1 hour, each ethanol solvent consumption 50L), collect the extract;

[0033] (2) Concentrate the extract at low temperature and under reduced pressure until it has no alcohol smell, and add an appropriate amount of water to dissolve it.

[0034] (3) Pass the water solution obtained in step (2) through HPD-300 type macroporous adsorption resin, and first use 3BV (BV: Bed Volume abbreviation, resin bed volume) water and 3BV 20 volume % ethanol to rinse until colorless, Discard eluent;

[0035] (4) Elute with 5BV 70% by volume of ethanol again, collect the ethanol eluate, and dry the eluate after recovering ethanol u...

Embodiment 2

[0036] The preparation of embodiment 2 sarsaparilla rhizome extract

[0037] Take 5.0 kg of Smilax smilax rhizome (purchased from Henan Anguo Medicinal Materials Wholesale Market, place of origin Hubei), heat and reflux extraction with 70% ethanol (volume) for 3 times (2h, 1h, 1h, each time the amount of ethanol solvent is 50L), and collect the extract ; Concentrate under reduced pressure at low temperature until there is no alcohol smell, add an appropriate amount of water to dissolve. The aqueous solution is passed through the AB-8 macroporous adsorption resin, first eluted to colorless with 3BV water and 3BV 15% ethanol (volume), removes macromolecular impurities such as sugar, discards, and then uses 5BV 80% ethanol (volume) Elution, collect the ethanol eluate, and dry the eluate after recovering the ethanol under reduced pressure to obtain 191 grams of the sarsaparilla rhizome extract (effective part of the sarsaparilla rhizome) of the present invention.

Embodiment 3

[0038] The preparation of embodiment 3 sarsaparilla rhizome extract

[0039] Take 5.0 kg of the rhizome of Smilax smilax (purchased from Henan Anguo Medicinal Materials Wholesale Market, place of origin Hubei), percolate and extract with 100L of 60% ethanol (volume) for 24 hours, collect the extract; concentrate under low temperature and reduced pressure until it has no alcohol smell, add appropriate amount of water to dissolve . The aqueous solution was passed through HPD-400 type macroporous adsorption resin, first eluted to colorless with 3BV water and 3BV 20% ethanol (volume), removed sugar and other macromolecular impurities, discarded, and then 5BV 70% ethanol (volume) Elution, collect the ethanol eluate, and dry the eluate after recovering the ethanol under reduced pressure to obtain 178 grams of the sarsaparilla rhizome extract (effective part of the sarsaparilla rhizome) of the present invention.

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Abstract

The invention provides a preparation method of a smilax rhizome extract, the smilax rhizome extract prepared by the method and application of the smilax rhizome extract to preparation of medicines for preventing, relieving and treating inflammation. The content of total saponin ingredients in the smilax rhizome extract is high, the total saponin ingredients account for over 50% of the weight of the smilax rhizome extract, pharmacodynamics tests prove that the therapeutic effect of the total saponin ingredients is remarkable, the total saponin ingredients are a principal medical effect material basis for treating gynecological inflammation through smilax, and can serve as a raw material of new drugs for effective part of traditional Chinese medicines.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to extracting an active extract containing total saponin compounds from the rhizome of the plant medicine sarsaparilla. The invention also relates to the preparation method and application of the active extract. Background technique [0002] The latest survey report of the World Health Organization pointed out that the most common disease among women is not cold but gynecological diseases (including cervical diseases, gynecological tumors, gynecological inflammation and various infections and complications caused by termination of unwanted pregnancy), of which gynecological inflammation accounts for 80% of gynecological diseases. About 41% of women of childbearing age in my country suffer from gynecological inflammation in varying degrees, and the incidence rate of married women is as high as 70%. Such diseases have seriously affected women's normal life, work, and physical and ...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61P29/00A61P31/04A61P15/00A61P15/02A61K125/00
CPCY02A50/30
Inventor 张铁军王丽莉刘素香王敏杰龚苏晓
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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