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Skin wound repair hydrogel and preparation method thereof

A technology for skin wounds and repairing water, which is applied in medical science, bandages, absorbent pads, etc., can solve problems such as degradation products that easily cause inflammation, large-area skin lesions are not suitable, and poor hygroscopicity and water permeability. Tissue growth, skin softening, and production-promoting effects

Active Publication Date: 2012-10-03
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its poor hygroscopicity and water permeability, it often leads to the formation of fluid accumulation on the wound surface and the reproduction of bacteria. Therefore, polymer films are mostly used for epidermal injuries, and are not suitable for large-area skin lesions.
Moreover, the degradation products of synthetic excipients in the body can easily cause adverse reactions such as inflammation.

Method used

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  • Skin wound repair hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Extraction of Aloe Vera Gum

[0024] Choose 10-year-old fresh aloe vera, wash it with tap water, wash it twice with distilled water, put it in a sterile operating table, and sterilize it with ultraviolet radiation for 30 minutes. After the sterilization is completed, use a scalpel to peel off the leaves to get the pulp. After the pulp is crushed with a juicer, put it into a 50mL centrifuge tube, centrifuge at 15000 rpm for 5min, and separate the supernatant, which is sterile aloe raw gum.

[0025] 2. Preparation of chitosan solution

[0026] Add 4g of chitosan into 100mL of 3% (v / v) acetic acid solution, stir and dissolve at 40°C to obtain a 4% (w / v) chitosan solution. Take 50mL chitosan solution and put it into a 3000kDa dialysis membrane, dialyze in 2L distilled water at 4°C for 6 days, and change the water every other day. Then the chitosan solution diluted by dialysis is placed in a beaker, placed in an oven at 50° C. to evaporate water and concentrate to 50 m...

Embodiment 2

[0033] 1. Extraction of Aloe Vera Gum

[0034] Choose 10-year-old fresh aloe vera, wash it with tap water, wash it twice with distilled water, put it in a sterile operating table, and sterilize it with ultraviolet radiation for 30 minutes. After the sterilization is completed, use a scalpel to peel off the leaves to get the pulp. After the pulp is crushed with a juicer, put it into a 50mL centrifuge tube, centrifuge at 15000 rpm for 5min, and separate the supernatant, which is sterile aloe raw gum.

[0035] 2. Preparation of chitosan solution

[0036] Add 4g of chitosan into 100mL of 3% (v / v) acetic acid solution, stir and dissolve at 40°C to obtain a 4% (w / v) chitosan solution. Take 50mL chitosan solution and put it into a 3000kDa dialysis membrane, dialyze in 2L distilled water at 4°C for 6 days, and change the water every other day. Then the chitosan solution diluted by dialysis is placed in a beaker, placed in an oven at 50° C. to evaporate water and concentrate to 50 m...

Embodiment 3

[0043] Choose 6-year-old fresh aloe vera, wash it with tap water, wash it twice with distilled water, then place it in a sterile operating table, and sterilize it with ultraviolet radiation for 30 minutes. After the sterilization is completed, use a scalpel to peel off the leaves to get the pulp. After the pulp is crushed with a juicer, put it into a 50mL centrifuge tube, centrifuge at 15000 rpm for 5min, and separate the supernatant, which is sterile aloe raw gum.

[0044] 2. Preparation of chitosan solution

[0045] Add 4g of chitosan into 100mL of 3% (v / v) acetic acid solution, stir and dissolve at 40°C to obtain a 4% (w / v) chitosan solution. Take 50mL chitosan solution and put it into a 3000kDa dialysis membrane, dialyze in 2L distilled water at 4°C for 6 days, and change the water every other day. Then the chitosan solution diluted by dialysis is placed in a beaker, placed in an oven at 60° C. to evaporate water and concentrate to 50 mL, and the pH value of the chitosan...

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Abstract

The invention discloses a skin wound repair hydrogel and a preparation method thereof. The skin wound repair hydrogel contains aloe original gel, chitosan, beta-sodium glycerophosphate and water; pH is 7.0-7.5. The preparation method mainly comprises the following steps: mixing 1-4% (w / v) chitosan solution and aloe original gel in volume ratio of 1: 1-2 at 2-10 degrees centigrade, then dropwise adding beta-sodium glycerophosphate aqueous solution, adjusting pH of solution to 7.0-7.5, and forming the hydrogel at 4-50 degrees centigrade. The skin wound repair hydrogel provided by the invention is capable of promoting generation of skin capillarity tubes, is beneficial to growth of tissue to protect nerve endings of wounds and reduce pain, is used for treating suppurative dermatosis, superficial dermatomycosis, skin trauma and ultraviolet dermatitis, and is featured with effects of diminishing inflammation, sterilizing, alleviating pain, absorbing heat, anti-swelling, softening skins, relieving pain and improving scars.

Description

technical field [0001] The invention specifically relates to a skin wound repairing hydrogel and a preparation method thereof. Background technique [0002] Dressings used in skin wound repair include traditional and synthetic dressings. Traditional dressings are mainly composed of cotton, soft linen, gauze and other materials, which are characterized by good water absorption, so as to keep the wound dry. However, traditional dressings cannot effectively prevent wounds from being infected. Moreover, traditional dressings tend to stick to the planed surface, and it is likely to damage the newly recovered wound surface again when it is removed. The polymer film of synthetic dressing has good elasticity and air permeability, and commonly used materials include polyurethane, polyethylene, silicone rubber, polytetrafluoroethylene, etc. However, due to its poor hygroscopicity and water permeability, it often leads to the formation of fluid accumulation on the wound surface and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/28A61L15/20A61L15/42
Inventor 张琳张璐陈世萱
Owner SOUTHERN MEDICAL UNIVERSITY
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