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Optimized adult first-line AIDS antiviral therapy program

A kind of AIDS and anti-virus technology, applied in the field of medicine, can solve the problem of low side effects

Inactive Publication Date: 2012-10-17
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a lack of satisfactory first-line HIV antiretroviral treatment drugs and regimens with low side effects

Method used

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  • Optimized adult first-line AIDS antiviral therapy program
  • Optimized adult first-line AIDS antiviral therapy program
  • Optimized adult first-line AIDS antiviral therapy program

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] In this example, the differences in therapeutic effects, side effects, etc. between the treatment scheme of using stavudine first and then zidovudine and other treatment schemes were compared.

[0067] 1. Method

[0068] 517 untreated adult HIV / AIDS patients screened by 10 research centers were randomly divided into two groups for the first time, and were given program A: D4T+3TC+NVP or B: AZT+3TC+NVP.

[0069] Both groups were followed up at 0.5, 1, 2, 3 months after treatment and every 3 months thereafter.

[0070] When the 6-month treatment was completed, group A was randomized for the second time and divided into long-term treatment group A and treatment scheme conversion group C, and D4T was replaced with AZT for continued treatment, and thereafter every 0.5, 1, 2, 3 month and thereafter every 3 months.

[0071] The long-term treatment group A and B and the conversion program group C were followed up for 1 year. Through multidisciplinary collaboration, carry out...

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Abstract

The invention provides an optimized adult first-line AIDS (Acquired Immune Deficiency Syndrome) antiviral therapy program. Concretely, the therapy program of the invention includes (a) a first stage: employing the stavudine-containing (D4T) program to treat for a period of time (such as 4-12 months); and (b) a second stage: replacing stavudine with zidovudine (AZT) for treatment. The therapy program of the invention not only gets a good therapeutic effect, but also can reduce the toxic and side effects of D4T and AZT, and is an equivalent and relatively safe first-line therapy program.

Description

technical field [0001] The invention belongs to the field of medicine, and more specifically relates to an optimized adult first-line AIDS antiviral treatment scheme and its application. Background technique [0002] With the use of Highly Active Antiretroviral Therapy (HAART for short) since the late 1990s, it can effectively control virus replication, reduce the spread of AIDS, rebuild the immune function of patients, and significantly reduce the incidence of AIDS and mortality rate [1] . However, since HAART cannot completely eliminate the HIV virus, patients are doomed to receive life-long treatment. [0003] With the prolongation of HAART use, more and more problems appear: long-term HAART treatment leads to adverse drug reactions and complications, including lipodystrophy and metabolic abnormalities, etc. [2-4] , seriously affecting the patient's body function, quality of life and medication compliance, and ultimately leading to treatment failure. In my country, ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P31/18
Inventor 李太生
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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