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Traditional Chinese medicine puffed granules and preparation method thereof

A technology of puffed granules and traditional Chinese medicine, which is applied in the field of medicine and can solve problems such as poor shape, unfavorable storage, packaging and storage, and easy moisture absorption.

Active Publication Date: 2014-12-17
SICHUAN XUYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the granules prepared according to the existing methods usually need to add a large amount of auxiliary materials to form the shape, and the shape of the granules is usually indeterminate, the particles are scattered, broken, poor in shape, poor in fluidity, and easy to absorb moisture, which is not conducive to storage, packaging and storage.

Method used

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  • Traditional Chinese medicine puffed granules and preparation method thereof
  • Traditional Chinese medicine puffed granules and preparation method thereof
  • Traditional Chinese medicine puffed granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Example 1 Tongmai Granules

[0079]

[0080] Existing process: the above three flavors, add water and decoct twice, the first time is 1.5 hours, the second time is 1 hour to combine the decoction, filter, the filtrate is concentrated to a relative density of 1.08, filter while it is hot, and the filtrate is concentrated to a relative density of 1.08 1.38~1.40 clear paste, add appropriate amount of sucrose powder, make granules, bulk density is about 0.62g / cm 3 , dried at low temperature (40-60° C.) to obtain 1000 g of granules, and divided into 100 bags.

[0081] The process of the present invention: the above three flavors are decocted twice with water, the first time is 1.5 hours, the second time is 1 hour and the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.08, filtered while hot, the filtrate is concentrated to a relative density of 1.08 1.38 ~ 1.40 clear paste, dry, crush, add appropriate amount of sucrose, make granu...

Embodiment 2

[0082] Example 2 Xia Sangju Granules

[0083]

[0084] Existing process: the above three flavors, decoct twice with water, each time for 1.5 hours, merge the decoction, filter, the filtrate is concentrated to 1 / 2 (V / W) of the crude drug amount, add 2 times the amount of 95% ethanol, fully Stir, stand overnight, filter, recover ethanol from the filtrate, concentrate under reduced pressure to a relative density of 1.25-1.26 (30°C), add an appropriate amount of sucrose powder, mix well, and make granules with a bulk density of about 0.55g / cm 3 , dried to obtain 1000g of granules, and then packed into 100 bags.

[0085] Technology of the present invention: above three flavors, decoct twice with water, each 1.5 hours, merge decoction, filter, and filtrate is concentrated to 1 / 2 (V / W) of crude drug amount, adds the 95% ethanol of 2 times amount, fully Stir, stand overnight, filter, recover ethanol from the filtrate, concentrate under reduced pressure to a relative density of 1.2...

Embodiment 3

[0086] Example 3 Shilintong Granules

[0087] name

prescription

Prescription amount

Amount of extract

Shilintong Granules

Desmodium

1500g

120-150g

[0088] Existing technology: get 1500g of Desmodium glabra, add water and decoct twice, each time 1 hour, merge the decoction, filter, the filtrate is concentrated to a relative density of 1.20 (thermal measurement), wait to be cooled to room temperature, add ethanol to make the containing The alcohol content reaches 65%, stir, stand still for 24 hours, filter, the filtrate is concentrated into a thick paste, add an appropriate amount of sucrose powder, and make granules, the bulk density is about 0.66g / cm 3 , dried to obtain 1000g of granules, and then packed into 100 bags.

[0089] The process of the present invention: get 1500g of Desmodium sativa, add water and decoct twice, each time for 1 hour, merge the decoction, filter, the filtrate is concentrated to a relative density of 1.20...

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Abstract

The invention belongs to the medical filed, and especially to Chinese medicine puffed granules and a preparation method thereof. The technology problem that the invention solves is to provide a traditional Chinese medicine puffed granules with smooth and compact texture and good fluidity, and the shapes of granules are ball-like. A material medicine of the traditional Chinese medicine puffed granules can be either a single-ingredient traditional Chinese medicine or a complex traditional Chinese medicine, and extraction and decoction processes thereof can be performed according to existing methods. Main differences lie in the processes of granulation and drying: 1) preparing the particles into particles with a bulk density being 0.78g / cm3 during the process of granulation; during the process of drying, 1) drying the particles at a low temperature of 40-60DEG C until the water content is 4-5%; 2)heating the granules at a high temperature of 65-95DEG C until the granules become puffed; 3)and maintaining the high temperature of 65-95DEG C to dry the granules until the water content in the granules is less than 2%.Then the traditional Chinese medicine puffed granules are obtained. The preparation method provided by the invention enables the spherical particles to have smooth and compact texture. The interior of a particle has a phenomenon of cavity puffing. The granules are not easily to be disintegrated, well shaped, of good fluidity and not easily to absorb moisture. Besides, when granule infusion, pastes are not formed on a bottom of a cup, which is brewed easily.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of traditional Chinese medicine expanded granules. Background technique [0002] At present, in order to facilitate the application of traditional Chinese medicine, the common dosage forms of compound Chinese medicine are granules, tablets, and capsules. There are also single Chinese medicines extracted and made into formula granules, and the formula of single Chinese medicine is prepared by clinicians. Mix the granules and drink it. The above-mentioned granules are usually obtained by decocting Chinese medicinal materials with water or extracting them with organic solvents such as ethanol to obtain extracts, then adding auxiliary materials to make soft materials, granulating and sizing the granules to obtain granules, and the granules can also be compressed into tablets or Capsules are made into tablets or capsules. However, the granules prepared accord...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J3/00A61K9/16A61K36/00
Inventor 高庆凌
Owner SICHUAN XUYANG PHARMA