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Water-soluble puffed granules for treating urolithiasis and preparation method thereof

An expanded granule, water-soluble technology, applied in the field of medicine, can solve the problems of unfavorable storage, packaging and storage, loose granules, poor shape, etc.

Inactive Publication Date: 2014-02-12
SICHUAN XUYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the granules prepared according to the existing methods usually need to add a large amount of auxiliary materials to form the shape, and the shape of the granules is usually indeterminate, the particles are scattered, broken, poor in shape, poor in fluidity, and easy to absorb moisture, which is not conducive to storage, packaging and storage.

Method used

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  • Water-soluble puffed granules for treating urolithiasis and preparation method thereof
  • Water-soluble puffed granules for treating urolithiasis and preparation method thereof
  • Water-soluble puffed granules for treating urolithiasis and preparation method thereof

Examples

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Effect test

Embodiment 1

[0067] Take the dry extract, crush it, add an appropriate amount of sucrose, and make granules with a bulk density of about 0.80g / cm 3 , first dry the granules at a low temperature of 50-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules are puffed; then maintain high temperature conditions and dry the granules to Below 2%, dry to obtain 250g of granules, pack into 250 bags, and get ready.

Embodiment 2

[0069] Take the dry extract, crush it, add appropriate amount of dextrin and sweetener to make granules, the bulk density is about 0.82g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 75-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granule moisture to Below 2%, dry to obtain 250g of granules, pack into 250 bags, and get ready. [The granules are sugar-free]

Embodiment 3

[0071] Take the dry extract, crush it, add an appropriate amount of dextrin, and make granules with a bulk density of about 0.86g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granules to Below 2%, dry to obtain 250g of granules, pack into 250 bags, and get ready. [The granules are sugar-free]

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Abstract

The invention belongs to the medical field, and especially to water-soluble puffed granules for treating urolithiasis and a preparation method thereof. The technology problem that the invention solves is to provide water-soluble puffed granules for treating urolithiasis with smooth and compact texture and good fluidity, and the shapes of granules are ball-like. Extraction and decoction of desmodium styracifolium can be performed according to existing methods. A main difference is to prepare the particles of the water-soluble puffed granules for treating urolithiasis into a compressed state. During a process of drying, water content in the particles is controlled at 4-5% at a low temperature, the particles are heated at a high temperature to become puffed and the granules are obtained after drying. The preparation method provided by the invention enables the spheroidic particles to have smooth and compact texture. The interior of a particle has a phenomenon of cavity puffing. The particles have the following advantages: no easy disintegration, attractive appearance, particle angle of repose of 10-25DEG ,high fluidity, no easy moisture absorption, fewer supplementary materials required ,no easy pasty object generation and easy operation when used in infusion. The water-soluble puffed granules for treating urolithiasis provided by the invention can be used as materials for preparing tablets and capsules, and the processes of tabletting and capsulationcan be performed according to regular processes.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to water-soluble Shilintong expanded granules and a preparation method thereof. Background technique [0002] At present, in order to facilitate the application of traditional Chinese medicine, the common dosage forms of compound Chinese medicine are granules, tablets, capsules, etc., and there are also single Chinese medicines extracted and made into formula granules. Shilintong granule clears dampness and heat, promotes diuresis and expels stones. It is used for urinary calculus, pyelonephritis, and cholecystitis caused by damp-heat in the lower energizer. [0003] Shilintong granules are usually obtained by decocting raw materials with water or extracting them with organic solvents such as ethanol to obtain extracts, and then adding auxiliary materials to make soft materials, then granulating and sizing the granules to obtain granules. However, the granules prepared accordin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/48A61K9/16A61J3/00A61P13/04
Inventor 高庆凌
Owner SICHUAN XUYANG PHARMA