Specificity-based multimodal three-dimensional optical tomography system and method

Abstract

Disclosed are a specificity-based multi-modal three-dimensional optical tomography system and a method thereof. The specificity-based multimodal three-dimensional optical tomography system includes an optical imaging submodule, a CT imaging submodule, a translation platform (102), a turntable (103), an electronic control system (106), a rotation control and a processing software platform ( 107). The electronic control system (106) is used to control the translation stage (102) and the turntable (103), and the rotation control and processing software platform (107) is used to establish the obtained optical signal intensity distribution of the target surface, the obtained CT discrete An equation of a linear relationship between the grid data and the distribution of an unknown internal self-illuminating light source, an objective function of dynamic sparse regularization in each iteration step is established for the equation, and a tomographic image is reconstructed. In addition, the specificity-based multi-modal three-dimensional optical tomography method includes the following steps: performing optical imaging to obtain the optical signal intensity of the imaging target body surface; performing CT imaging to obtain structural body data; establishing the obtained optical signal intensity of the target surface. An equation for the linear relationship between signal intensity distribution, acquired CT discrete grid data, and distribution of an unknown internal self-illuminating light source; establishing an objective function of dynamic sparse regularization in each iteration for the equation; and reconstructing a tomographic image. The tomographic imaging system and method of the present invention can realize the overall three-dimensional tomographic imaging of the object to be imaged, avoid the dependence on the prior knowledge of the general distribution position, improve the robustness of image reconstruction, and reduce the dependence on the selection of regularization parameters sex.

Description

technical field [0001] The invention relates to an imaging system, in particular to a specificity-based multi-mode three-dimensional optical tomography system and method. Background technique [0002] Among the many modalities of molecular imaging, optical molecular imaging is a new technology that has developed rapidly in recent years. Optical molecular imaging technology can perform continuous in vivo imaging of the whole organism in real time and non-invasively, and visualize the change information of the organism's physiology, metabolism, and cell molecular level through three-dimensional tomographic imaging methods, which has promoted the application of related biomedical research. develop. [0003] 3D optical tomography is an ill-conditioned inverse problem, because in the imaging process, the information that can be measured to locate the reconstruction target is very limited, so the inverse problem usually has no unique definite solution. In order to obtain reasona...

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Problems solved by technology

[0003] 3D optical tomography is an ill-conditioned inverse problem, because in the imaging process, the information that can be measured to locate the reconstruction target is very limited, so the inverse problem usually has no unique definite solution

These limitations have severely restricted the application of optical three-dimensional tomography

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