Preparation method of toltrazuril solid dispersion
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of solid dispersion and toltrazuril, which is applied in non-active ingredients medical preparations, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc. and other problems, to achieve the effect of improving solubility and simple preparation process
Inactive Publication Date: 2012-10-31
QINGDAO LVMAN BIOLOGICAL ENG
View PDF4 Cites 1 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0003] Due to the poor water solubility of Toltrazuril, it has brought gre
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment
[0018] A kind of preparation method of Toltrazuril solid dispersion, carry out as follows: (every part is calculated by 10g)
[0019] (1) Take by weight 100 parts of Toltrazuril (over 80 mesh sieves), 200 parts of polyvinylpyrrolidone, and 600 parts of ethanol;
[0020] (2) The toltrazuril and polyvinylpyrrolidone are mixed and stirred until uniform;
[0021] (3) The mixture obtained in (2) is quickly added to ethanol, stirred evenly, heated to evaporate the ethanol to obtain a precipitate, dried and pulverized to obtain Toltrazuril solid dispersion.
[0022] Example:
[0023] A kind of preparation method of Toltrazuril solid dispersion, carry out as follows: (every part is calculated by 10g)
[0024] (1) Take by weight 120 parts of Toltrazuril (over 80 mesh sieves), 250 parts of polyvinylpyrrolidone, and 800 parts of ethanol;
[0025] (2) The toltrazuril and polyvinylpyrrolidone are mixed and stirred until uniform;
[0026] (3) The mixture obtained in (2) is quickly added...
Embodiment 3
[0028] A kind of preparation method of Toltrazuril solid dispersion, carry out as follows: (every part is calculated by 10g)
[0029] (1) Take by weight 150 parts of Toltrazuril (over 80 mesh sieves), 300 parts of polyvinylpyrrolidone, and 1000 parts of ethanol;
[0030] (2) The toltrazuril and polyvinylpyrrolidone are mixed and stirred until uniform;
[0031] (3) The mixture obtained in (2) is quickly added to ethanol, stirred evenly, heated to evaporate the ethanol to obtain a precipitate, dried and pulverized to obtain Toltrazuril solid dispersion.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
A preparation method of a toltrazuril solid dispersion relates to the field of animal medicines. The toltrazuril solid dispersion is prepared by uniformly and sequentially mixing the following components in part by weight: 10-15 parts of toltrazuril (passing through an 80-mesh sieve), 20-30 parts of polyvinyl pyrrolidone and 60-100 parts of ethanol. The preparation method comprises the following steps: (1), weighing 10-15 parts of toltrazuril (passing through the 80-mesh sieve), 20-30 parts of polyvinyl pyrrolidone and 60-100 parts of ethanol in part by weight; (2), mixing the toltrazuril and the polyvinyl pyrrolidone, and stirring uniformly; and (3), quickly adding a mixture obtained in the step (2) into the ethanol, stirring uniformly, heating to evaporate the ethanol and obtain the precipitate, drying, and pulverizing to obtain the toltrazuril solid dispersion. The preparation method is simple in process; the solubility of the toltrazuril is significantly improved; and the dissolution of the toltrazuril is about 2 times that of an ordinary toltrazuril preparation (soluble powder or oral liquid).
Description
technical field [0001] The invention relates to the field of animal medicine, in particular to a preparation method of Toltrazuril solid dispersion. Background technique [0002] Toltrazuril is a white or off-white crystalline powder. It is a new type, high-efficiency, and low-toxicity anticoccidiostat, and is widely used in the prevention and treatment of chicken coccidiosis. [0003] Due to the poor water solubility of Toltrazuril, it has brought great troubles to clinical application and affected its popularization and use. Therefore developing a new technology to overcome the above-mentioned shortcoming of toltrazuril is one of the new issues to be solved urgently by scientific research technicians in this field. Contents of the invention [0004] The purpose of the present invention is to overcome above-mentioned disadvantages, and provide a kind of preparation method of Toltrazuril solid dispersion with simple process, stable quality and good water solubility. [0...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more