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Quality detection method for 29-componnet stagnation dissipation powder as Tibetan medicinal composition and preparations thereof

A technology of composition and Tibetan medicine, applied in the field of quality inspection of Tibetan medicine compositions and preparations thereof, can solve the problems of limit inspection, strong toxicity, and no reports on quality inspection of twenty-nine flavors that can dissipate, and achieves a guaranteed Safe, effective and accurate quality inspection

Active Publication Date: 2012-10-31
JINHE TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The iron rod hammer in the prescription contains aconitine, which has high pharmacological activity and medicinal value, but it also has strong toxicity. Although the toxic components are significantly reduced after processing, the safety of medicinal use cannot be guaranteed; Fragrant Aristolochia contains aristolochic acid, which can cause adverse reactions such as kidney damage
There were no identification and content determination items in the original quality standard, and no limit inspection was carried out on the aconitine contained in the iron rod hammer and the aristolochic acid contained in the woody Aristolochia, which made the preparation a potential safety hazard
At the same time, the preparation did not identify and measure its active ingredients, so that the effective use of the preparation could not be ensured
Literature and patents have not seen reports on the quality detection of Erjiuwei can dissipate

Method used

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  • Quality detection method for 29-componnet stagnation dissipation powder as Tibetan medicinal composition and preparations thereof
  • Quality detection method for 29-componnet stagnation dissipation powder as Tibetan medicinal composition and preparations thereof
  • Quality detection method for 29-componnet stagnation dissipation powder as Tibetan medicinal composition and preparations thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0325] Embodiment 1: the quality detection method that twenty-nine flavors can dissipate

[0326] Identification:

[0327] A. Identification of frankincense

[0328] Get 3g of Tibetan medicine composition twenty-nine flavors that can dissipate powder, add 25ml of ether, sonicate for 15min, filter, evaporate the filtrate to dryness, add 2ml of methanol to the residue to dissolve, and use it as the test solution; Diethyl ether 30ml, sonicate for 15min, filter, evaporate the filtrate to dryness, add 2ml of methanol to the residue to dissolve, and use it as a reference medicinal solution; test according to thin-layer chromatography (Appendix VI B of "Chinese Pharmacopoeia" 2010 edition), absorb the above two 5 μl of each solution was spotted on the same silica gel G thin-layer plate, and xylene-ethyl acetate with a volume-to-volume ratio of 8:1.5 was used as a developer, developed, taken out, and dried in the air; sprayed with 1% vanillin sulfate ethanol solution, heated at 105°...

Embodiment 2

[0363] Embodiment 2: Quality detection method of Erjiuwei Nengxiao Pills

[0364] Identification:

[0365] A. Identification of frankincense

[0366] Take 3g of the powder of Erjiuwei Nengxiao Pills of Tibetan medicine composition, add 25ml of ether, ultrasonically treat for 15min, filter, evaporate the filtrate to dryness, add 2ml of methanol to the residue to dissolve, and use it as the test solution; Add 30ml of ether, sonicate for 15min, filter, evaporate the filtrate to dryness, add 2ml of methanol to the residue to dissolve, and use it as a reference medicinal solution; according to the test of thin layer chromatography (Appendix VI B of "Chinese Pharmacopoeia" 2010 edition), absorb the above two 5 μl of each solution was spotted on the same silica gel G thin-layer plate, and xylene-ethyl acetate with a volume-to-volume ratio of 8:1.5 was used as the developer, developed, taken out, and dried in the air. Spray with 1% vanillin sulfuric acid ethanol solution and heat at...

Embodiment 3

[0402] Example 3: Quality detection method of Erjiuwei Nengxiao Tablets

[0403] Identification:

[0404] A. Identification of frankincense

[0405] Take 3g of Tibetan medicine composition Erjiuwei Nengxiao tablet powder, add 25ml of diethyl ether, ultrasonically treat for 15min, filter, evaporate the filtrate to dryness, add 2ml of methanol to the residue to dissolve, as the test solution; take 0.5g of frankincense reference medicinal material, Add 30ml of ether, sonicate for 15min, filter, evaporate the filtrate to dryness, add 2ml of methanol to the residue to dissolve, and use it as a reference medicinal solution; according to the test of thin layer chromatography (Appendix VI B of "Chinese Pharmacopoeia" 2010 edition), absorb the above two 5 μl of each solution was spotted on the same silica gel G thin-layer plate, and xylene-ethyl acetate with a volume-to-volume ratio of 8:1.5 was used as the developer, developed, taken out, and dried in the air. Spray with 1% vanillin...

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Abstract

The invention discloses a quality detection method for 29-componnet stagnation dissipation powder as a Tibetan medicinal composition and preparations thereof. IN the quality detection method, thin layer chromatography is used to carry out qualitative identification on frankincense, piperine and myristica fragrans in the 29-componnet stagnation dissipation powder, high performance liquid chromatography (HPLC) is used to carry out limit test on aconitine and costustoot aristolochic acid in the 29-componnet stagnation dissipation powder, and simultaneously, the high performance liquid chromatography is used to carry out quantitative detection on aloe-emodin, chrysophanol, rhein, emodin, emodin monomethyl ether and hydroxysafflor yellow A in the 29-componnet stagnation dissipation powder. According to the invention, the thin-layer identification method for the frankincense, the piperine and the myristica fragrans, the limit test method for the aconitine and the costustoot aristolochic acid, and the content determination method for the aloe-emodin, the chrysophanol, the rhein, the emodin, the emodin monomethyl ether and the hydroxysafflor yellow A are developed, so that the quality standard of a product is increased, and drug safety and effectiveness are guaranteed while the 29-componnet stagnation dissipation powder and the preparations thereof are used for treating diseases.

Description

technical field [0001] The invention relates to a quality detection method of a Tibetan medicine composition and its preparation, in particular to a quality detection method of the Tibetan medicine composition Ernine Flavors Energy Dissipation and its preparation. Background technique [0002] The twenty-nine flavors that can dissipate are recorded in "Clinical Notes of Tibetan Medicine". The author, Yundan Gyatso, was a famous Tibetan doctor in the 13th century. After years of clinical practice, he concocted the twenty-nine flavors that can dissipate . Because of its good curative effect on women's uterine fibroids and ovarian cysts, it has been highly praised by Tibetan medical scientists in the past dynasties. Twenty-nine flavors can dissipate from Tibetan woody fragrance, cold water stone (calcined), myrobalan, millet pepper, alkali flower, nutmeg, longan, rhubarb, iron hammer, safflower, woody aristolochia, ambrette, etc. 29 Composed of flavored medicines, it has the ...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
Inventor 孙泰俊孙绪丁刘玉芹任松鹏魏永义
Owner JINHE TIBETAN MEDICINE
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