The invention discloses an anti-dust efficient cleaning device for double-layer lifting transversely-moving-type parking equipment. The anti-dust efficient cleaning device comprises a garage body, thegarage body comprises an upper layer garage main body and a lower layer garage main body which are arranged in a perpendicular collineation mode, and anti-dust mechanisms are arranged on the two sides of the garage body correspondingly. A cleaning mechanism is arranged in the garage body, vehicle-carrying plates are arranged at the bottoms of inner cavities of the upper layer garage main body andthe lower layer garage main body correspondingly, and dust collectors and dust collecting boxes are arranged at the bottoms of the vehicle-carrying plates correspondingly. The dust collectors are arranged in the dust collecting boxes, and a controller is arranged on one side of the garage body. Each anti-dust mechanism comprises a forward and reverse motor, a main gear, an auxiliary gear, a firstunreeling cylinder, a second unreeling cylinder, an anti-dust curtain, a rope and a connecting rod, and the forward and reverse motor is mounted at the top of the inner side wall of the garage. According to the anti-dust efficient cleaning device for the double-layer lifting transversely-moving-type parking equipment, the structure is simple, operation is convenient, all-direction cleaning of a garage can be achieved, under the non-using state, dust preventing can further be conducted, and practicability is high.