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Absorbable composite biomaterial and preparation method thereof

A technology of composite materials and bioglass, which is applied in medical science, prosthesis, surgery, etc., can solve the problems of inflammatory response, tissue damage, and polylactic acid without biological activity, and achieve bioactive, high-strength, and degradable strength. Effect

Active Publication Date: 2014-08-06
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polylactic acid has no biological activity, and its acidic degradation products can cause inflammation in the body and cause local tissue damage.
[0006] From the above analysis, it can be seen that a single bioglass, chitosan and polylactic acid are not ideal orthopedic biomaterials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 40 grams of CaO-P with an average particle size of 100 μm after ball milling 2 o 5 -SiO 2 Calcium-phosphorus-silicate bioglass, 10 grams of chitosan with a particle size of 150 μm and 50 grams of poly-L-lactic acid with a molecular weight of about 400,000 were mechanically mixed to obtain a composite material. The composite material is placed in the mold and the temperature is heated to 185°C. Carry out hot molding, the pressure of hot molding is 10MPa, keep the pressure for 20 minutes, and cool to obtain the molding material. The mechanical property test shows that the compressive strength is 113.5Mpa, and the elastic modulus is 6.4GPa. Then the bone nail is made by machining.

Embodiment 2

[0027] 20 grams of Na2O-CaO-P2O5-SiO2 series bioglass with an average particle size of 100 μm after ball milling, 10 grams of chitosan with a particle size of 150 μm and 70 grams of poly(D, L)-lactic acid with a molecular weight of about 400,000 were passed through the Mechanical mixing results in a composite material. The composite material was placed in an extruder, and the temperature of the barrel of the extruder was 180°C. The mechanical properties of the obtained molding material were tested, and the compressive strength was 105.7Mpa, and the elastic modulus was 5.6GPa. Then the internal fixation plate is made by machining.

Embodiment 3

[0029] The difference between this example and Example 1 is that polylactic acid is a copolymer of poly(L-lactic acid) and poly(D, L)-lactic acid. The test results of its mechanical properties are: the compressive strength is 111.6MPa, and the elastic modulus is 6.2 GPa, others are the same as in Example 1.

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Abstract

The invention discloses an absorbable composite biomaterial and a preparation method thereof. The prepared absorbable composite biomaterial comprises, by mass, 10%-50% of bioglass, 5%-10% of chitosan and 40%-85% of polylactic acid, and the sum of the weight percent of raw materials is 100%. The polylactic acid is poly L-lactic acid or poly (D, L)-lactic acid or a copolymer of the poly L-lactic acid and the poly (D, L)-lactic acid. The absorbable composite biomaterial is good in biocompatibility, bioactive, degradable and high in strength. The preparation method of the absorbable composite biomaterial includes the steps of mixing the bioglass, the chitosan and the polylactic acid according to the formula amount and then performing hot hubbing or hot extrusion so that the absorbable composite biomaterial is prepared.

Description

technical field [0001] The invention belongs to a composite biological material and a preparation method, in particular to a bioglass / chitosan / polylactic acid composite biological material and a preparation method. Background technique [0002] Bone internal fixator is an indispensable medical device for the treatment of orthopedic diseases. At present, the commonly used internal fixators are made of metal materials or absorbable polymer materials. There are problems such as the need for secondary surgery to remove metal materials, high elastic modulus, stress shielding effect, and foreign bodies in the body. The most commonly used absorbable material, polylactic acid, has degradation products of acidic small molecular compounds, which lead to local inflammatory reactions. In addition, polylactic acid has no osteoinductive and osteoconductive activities. [0003] Bioglass (BG) is a class of biomaterials with excellent performance. It has good biocompatibility, osteoconducti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/02A61L31/14A61L27/20A61L27/18A61L27/10A61L27/58
Inventor 雷伟吴子祥李阳于龙吴剑维张扬藏渊刘峙辰
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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