Chromatographic column

A chromatographic column and column technology, which is applied in the field of chromatographic columns, can solve problems such as the generation of air bubbles, the decline in the separation ability of chromatographic columns, and the tendency to react

Active Publication Date: 2012-11-14
黄山华绿园生物科技有限公司
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  • Abstract
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Problems solved by technology

Commonly used adsorbents mainly include resin, silica gel, alumina, etc. After the chromatography column has been used for a period of time, some viscous components in the sample to be separated will remain on the adsorbent, which will cause the adsorbent to harden and the separation of the chromatography column will be difficult. The capacity is reduced. At the same time, when the resin is cleaned, the discharge port for the adsorbent is small, and the unloading of the adsorbent is cumbersome, especially for chromatography columns with larger diameters and volumes used in industrial production.
In addition, in the separation process of column chromatography, the eluent is often composed of organic solvents. After these organic solvents are mixed with water components, they are prone to react and generate bubbles, which affect the distribution of each component in the sample and the separation of the sample. seperate effect

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Embodiment Construction

[0008] The primary purpose of the present invention is to provide a chromatographic column that facilitates the unloading of the adsorbent, and facilitates the cleaning and reuse of the adsorbent. The scheme it takes is as follows: figure 1 As shown, a chromatography column includes a column body 10 and an adsorbent filled in the column body 10, and the column body 10 is also provided with a stirring device for stirring and loosening the adsorbent. The stirring device set here has two main functions. One is to stir the adsorbent before the adsorbent is unloaded, so that the hardened eluent is loosened, which is convenient for unloading and cleaning of the eluent; After arriving at the column 10, the eluent and water will act on the bubbles generated between the gaps of the adsorbent, which can be discharged by the agitation of the stirring device, so as to prevent the influence of the bubbles on the liquid distribution and separation effect of the eluent. The cylinder can be m...

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Abstract

The invention discloses a chromatographic column, which comprises a column body and an adsorbent filled in the column body, wherein a stirring device for stirring and loosening the adsorbent is also arranged in the column body. The stirring device is arranged in the column body so that the stirring device starts stirring and loosening the adsorbent when the adsorbent needs to be cleaned, the adsorbent is conveniently unloaded from the column body, the cleaning operation of the adsorbent is simple and feasible, and the reutilization of the adsorbent is conveniently realized.

Description

technical field [0001] The invention relates to the field of separation of chemical products, in particular to a chromatographic column. Background technique [0002] Column chromatography separation technology is currently widely used in the pharmaceutical industry, biochemical industry, food engineering and other fields, and is one of the important means to separate chemical products and prepare high-purity substances. Column chromatography technology, also known as column chromatography technology, is filled with insoluble granular adsorbent in the chromatography column, and the adsorbent forms a stationary phase, and the sample to be separated is added to the chromatography column and eluted with an eluent , the eluent constitutes the mobile phase. During the process of eluting the sample from the column, according to the different distribution coefficients of the components in the sample in the stationary phase and the mobile phase, the components are distributed repeat...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/22
Inventor 揭国良蔡亚章志强邹敏亮靳锁陈克
Owner 黄山华绿园生物科技有限公司
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