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A method for preparing electrostatically self-assembled drug carried layer

A technology of electrostatic self-assembly and drug-loaded layer, which is applied in the direction of drug equipment, medical science, balloon catheters, etc., can solve the problems of single drug and no better solution, achieve good therapeutic effect, rich preparation methods, reduce The effect of loss rate

Active Publication Date: 2013-01-02
LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example: 1. How to keep the drug on the outer surface of the balloon from being washed out by the blood in the blood vessel during the process of sending the balloon into the lesion through the catheter; 2. How to increase the amount of the drug transferred to the diseased tissue; 3. , The substance loaded by the existing drug balloon is generally a single drug, it is difficult to play a better comprehensive treatment effect on the lesions of in-stent restenosis
These have become difficult problems in the preparation of drug balloons, and there is currently no better solution

Method used

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  • A method for preparing electrostatically self-assembled drug carried layer
  • A method for preparing electrostatically self-assembled drug carried layer
  • A method for preparing electrostatically self-assembled drug carried layer

Examples

Experimental program
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Effect test

no. 1 example

[0043] A drug balloon for treating blood vessel stenosis is prepared by using a nylon balloon. Firstly, the surface modification pretreatment is carried out: at 25° C., the cleaned nylon balloon is immersed in an ethanol solution with a volume concentration of 75% for 30 minutes.

[0044] Then charge-loaded surface treatment: immerse the balloon in a solution of 3-aminopropyltriethoxysilane with a weight-volume concentration of 5 mg / ml and a pH of 3.8, perform adsorption equilibrium for 20 minutes, wash with distilled water for 30 seconds, and blow with air. dry, the surface of the balloon is positively charged under aqueous conditions.

[0045] Next, carry out electrostatic self-assembly: dip the above-mentioned positively charged balloon into a mixed ethanol solution of paclitaxel and hyaluronic acid, wherein the weight volume concentration of paclitaxel is 0.5 mg / ml, and the weight volume concentration of hyaluronic acid is 2.5 mg / ml , adsorption equilibrium for 20 minutes...

no. 2 example

[0047] A drug balloon for treating blood vessel stenosis is prepared by using a nylon balloon. Firstly, the surface modification pretreatment is carried out: at 30° C., the balloon is immersed in an ethanol solution with a volume concentration of 85% for 60 minutes.

[0048] Then charge-loaded surface treatment: immerse the balloon in a solution of 3-aminopropyltriethoxysilane with a weight-volume concentration of 10 mg / ml and a pH of 5.5, perform adsorption equilibrium for 10 minutes, wash with distilled water for 30 seconds, and blow with air. dry, the surface of the balloon is positively charged under aqueous conditions.

[0049] Next, electrostatic self-assembly is carried out: the above-mentioned positively charged balloon is immersed in a mixed ethanol solution of paclitaxel and hyaluronic acid, wherein the weight volume concentration of paclitaxel is 0.5 mg / ml, and the weight volume concentration of hyaluronic acid is 5 mg / ml. Adsorption balance for 10 minutes, washed ...

no. 3 example

[0051] The polyether amide (Pebax) balloon was used to prepare the drug balloon for the treatment of vascular stenosis. Firstly, surface modification pretreatment is carried out: low-temperature plasma treatment is carried out on the surface of the balloon by using plasma treatment equipment. Among them, the plasma gas is oxygen; the output power is 400W, the frequency is 50MHz; the processing time is 5 minutes, and the air pressure is 30Pa.

[0052] Then charge-loaded surface treatment: immerse the balloon in a solution of 3-aminopropyltriethoxysilane with a weight-volume concentration of 15 mg / ml and pH=3.8, perform adsorption equilibrium for 10 minutes, wash with distilled water for 30 seconds, and blow with air. dry, the surface of the balloon is positively charged under aqueous conditions.

[0053] Next, carry out electrostatic self-assembly: immerse the above-mentioned positively charged balloon into a mixed ethanol solution of paclitaxel and heparin sodium, wherein the...

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Abstract

The invention provides a method for preparing an electrostatically self-assembled drug carried layer. The method includes (1) performing surface modification pretreatment on a medical apparatus; (2) performing charge load surface pretreatment on the medical apparatus to form charge, which is the same to the charge carried by a first weak polyelectrolyte, on the surface of the medical apparatus; (3) preparing solution of a second weak polyelectrolyte and solution of a third weak polyelectrolyte, dissolving a drug in the second weak polyelectrolyte solution or the third weak polyelectrolyte solution; (4) soaking the medical apparatus with charge carried surface in the second weak polyelectrolyte solution, taking out, washing; (5) soaking the medical apparatus in the third weak polyelectrolyte solution, taking out, washing; and (6) repeating the step (4) and the step (5) alternately to form alternate electrostatically self-assembled drug carried layer with a desired drug density on the surface of the medical apparatus. The drug is included in the weak polyelectrolyte molecule layer.

Description

technical field [0001] The invention relates to the field of medical device preparation, in particular to a method for preparing an electrostatic molecular layer self-assembly drug-loaded layer. Background technique [0002] In many clinical treatments, medical devices are used to carry drugs into the human body, and then release a sufficient amount of drugs when they reach the lesion site, so as to obtain better comprehensive treatment effects. The drug balloon catheter for the treatment of coronary heart disease is particularly typical. [0003] Coronary heart disease is the most common heart disease. It refers to myocardial dysfunction or organic disease caused by coronary artery stenosis and insufficient blood supply, so it is also called ischemic cardiomyopathy. The etiology is due to the formation of atherosclerotic plaques on the walls of the coronary arteries that supply the heart itself, resulting in narrowing of the lumen of the blood vessels and causing heart dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/16A61L31/16A61M25/10A61M31/00
Inventor 申峰张德元
Owner LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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