Pharmaceutical composition for treating constipation and application thereof

A technology for treating constipation and composition, which is applied in the direction of drug combination, medical raw materials derived from bacteria, and pharmaceutical formulations, etc., can solve problems such as affecting the absorption of trace elements, delaying gastric emptying, increasing the burden on the intestinal tract, etc., and achieving the effect of promoting colonization.

Inactive Publication Date: 2013-12-25
李宁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] A large amount of dietary fiber supplementation from the diet requires a considerable amount of food containing dietary fiber, which may increase the burden on the gastrointestinal tract of the patient, causing delayed gastric emptying, resulting in abdominal distension, epigastric discomfort, belching, loss of appetite, indigestion and other symptoms ; and includes a large amount of insoluble dietary fiber, which can increase the volume of stool, thereby increasing the burden on the intestinal tract, and excessive insoluble dietary fiber will affect the absorption of trace elements

Method used

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  • Pharmaceutical composition for treating constipation and application thereof
  • Pharmaceutical composition for treating constipation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Weigh the commercially available bacterial strain activity respectively to be 10 8 CFU / g of Bacillus subtilis inoculum, Lactobacillus acidophilus and Lactobacillus bulgaricus each 0.5g to make mixed probiotics inoculum, with 20g inulin (commercially available) and 16g glutamine (commercially available) in Mix evenly at -5~5°C to make powder.

Embodiment 2

[0053] Weigh the commercially available strain activity as 10 8 CFU / g of Bacillus subtilis bacterial agent, Lactobacillus acidophilus bacterial agent and Lactobacillus bulgaricus bacterial agent each 0.6g to make mixed probiotic bacterial agent, and 25g polydextrose (commercially available) and 18g glutamine (commercially available) in Mix evenly at -5~5°C to make powder.

Embodiment 3

[0055] Weigh the commercially available strain activity as 10 8 CFU / g of Bacillus subtilis inoculum, Lactobacillus acidophilus and Lactobacillus bulgaricus each 0.4g to make mixed probiotics inoculum, with 15g isomaltooligosaccharide (commercially available) and 14g glutamine (commercially available ) Mixed uniformly at -5~5°C to make a powder.

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Abstract

The invention discloses a pharmaceutical composition for treating constipation and application of the pharmaceutical composition. The pharmaceutical composition contains the following effective components in parts by weight: 10-30 parts of water-soluble dietary fiber, 10-20 parts of glutamine and 1-3 parts of mixed probiotics microbial inoculums consisting of bacillus subtilis, lactobacillus acidophilus and lactobacillus bulgaricus. The pharmaceutical composition has the efficacies of softening excrement, promoting intestine peristalsis, restoring intestinal flora balance, repairing impaired intestinal mucosa, restoring the normal physiological function of intestinal tracts, and treating constipation fundamentally. The components of the composition achieve respective effects to alleviate constipation symptoms, and promote mutually and cooperate with each other to enhance curative effects, and the use effect of the pharmaceutical composition is obviously better than single use of each component.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a pharmaceutical composition for treating constipation and its application. Background technique [0002] Constipation is a group of symptoms characterized by decreased defecation frequency, difficult or incomplete defecation, dry and hard stool, and is a very common clinical symptom. The incidence of constipation in Western countries is about 6%-28%. The prevalence rate is between 3% and 17.6%. Long-term constipation seriously affects the patient's health and quality of life, and can lead to complications such as hemorrhoids, anal fissure, and colon cancer. [0003] At present, most patients with constipation mainly use various laxatives to relieve symptoms, but laxatives generally cause diarrhea in a short period of time, and long-term use has serious side effects, and will lead to laxative dependence, and constipation can be aggravated after drug withdrawal. [0004] At p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/74A61P1/10A61K35/742A61K35/747
Inventor 李宁虞文魁姜军陈启仪沈娟红韦瑶
Owner 李宁
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