Application of nafamostat mesilate in preparing drugs for preventing and curing ischemic cerebral apoplexy

A technology of nafamostat mesylate and ischemic stroke, applied in the field of medicine
CN102871998AInactive Publication Date: 2013-01-16JIANGSU DURUI PHARMACEUTICAL CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU DURUI PHARMACEUTICAL CO LTD
Publication Date
2013-01-16
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention relates to the technical field of drugs and aims to provide a new use of nafamostat mesilate in preparing drugs for preventing and curing ischemic cerebral apoplexy. Preoperative preventative administration or postoperative therapeutic administration is performed on a classical permanent cerebral ischemia model (permanent middle cerebral artery occlusion-pMCAO) and a classical cerebral ischemia reperfusion model (transient middle cerebral artery occlusion-tMCAO) by the invention, respectively, and the results show that the nafamostat mesilate is remarkable in effect of resisting the ischemic cerebral apoplexy. At a dosage point appointed by experiments, the nafamostat mesilate can be used for obviously improving animal behavior dysfunctions caused by ischemia and lowering the cerebral infarction rate of permanent cerebral ischemia and cerebral ischemia reperfusion rats. Prompted by research results, the nafamostat mesilate can be used for preventing and curing the ischemic cerebral apoplexy.
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Description

Technical field:

[0001] The invention relates to the technical field of medicine, in particular to the new application of nafamostat mesylate for preventing and treating ischemic cerebral apoplexy. Background technique:

[0002] According to statistics in recent years, there are about 1.3 to 1.5 million new cases of cerebral apoplexy in my country every year, and about 1 million deaths, which is 4 to 5 times higher than that in European and American countries. At present, the incidence of stroke in my country is increasing at an annual rate of nearly 9%. Stroke has the characteristics of high morbidity, high mortality and high disability rate, which brings a heavy burden to individuals, families and society. Ischemic stroke accounts for 70% of the total number of stroke patients. It refers to the disorder of cerebral blood flow and ischemic necrosis of brain tissue caused by various reasons, resulting in corresponding neurological deficit symptoms. Clinically common stroke...

Claims

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