Medicinal composition for therapy or adjuvant therapy of aids, preparation method of medicinal composition and application of medicinal composition

A technology of adjuvant therapy and composition, applied in the field of compound traditional Chinese medicine preparations, can solve the problems of toxic and side effects, cannot fundamentally eliminate HIV, and is expensive, and achieves the improvement of the number of CD8+ cells, excellent clinical treatment effect, and uniform quality control. Effect

Inactive Publication Date: 2013-02-06
宋福德 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But Western medicine antiviral therapy has the following problems: (1) HIV cannot fundamentally be eliminated, even if HIV is suppressed to an undetectable level in plasma for a long time, HIV is still replicating at a low level; (2) drug resistance of HIV and drug resistance Adverse reactions: After 4 to 5 years of clinical application of HAART, the drug resistance can be as high as 70%. At the same time, due to the relatively large toxic and side effects of most chemotherapeutic drugs, the compliance of patients is reduced, and 25% of patients will stop HAART; (3) Limitation of indications: For HIV-infected patients with CD4+T cells>400 / μl and plasma HIV RNA30%; (4) Expensive : Patients who use HAART need about 80,000 to 100,000 yuan per year. At present, only 400 to 500 patients can receive HAART at their own expense each year. The vast majority of poor AIDS patients in my country are in a state of no drug available

Method used

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  • Medicinal composition for therapy or adjuvant therapy of aids, preparation method of medicinal composition and application of medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Weigh 16.3kg of scutellaria baicalensis, 16.3kg of honeysuckle, 16.3kg of tripterygium wilfordii, 8.2kg of double-faced needle, 6.5kg of Qinpi, 16.3kg of Polygonum cuspidatum, 4.9kg of aconite, 8.2kg of angelica, 3.3kg of white pepper, 3.3kg of rhubarb, 7.3kg of Galla gall and 6.5kg of licorice, take Zhifuzi and fry for 2 hours, then add honeysuckle, tripterygium twig, LMZ, Qinpi, Polygonum cuspidatum, Zhifuzi, angelica, white pepper, rhubarb, gallnut and licorice, add water to boil, add Scutellaria baicalensis after boiling, Decoct 3 times, add 10 times of water each time, 1.5 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.28-1.32 at 50°C, dry under reduced pressure at 60-65°C, Crush it into a fine powder of dry paste, that is, too.

Embodiment 2

[0095] Embodiment 2: Preparation of borneol and one-fold hexagonal dextrin

[0096] Take beta cyclodextrin and add 3 times the amount of 20% ethanol, stir to make a paste; take another 2.5kg of borneol, dissolve the borneol with 10 times the amount of 95% ethanol, and press the ratio of borneol:beta cyclodextrin = 1:4 , slowly add the borneol solution to the above-mentioned beta-cyclodextrin paste under stirring, grind it repeatedly for 30 minutes with a colloid mill, and gradually adjust the grinding gap to 5 μm, take the ground paste, and blow it with cold air until it is nearly dry , dried at a temperature of 35°C-40°C, crushed into fine powder, and obtained.

Embodiment 3

[0097] Embodiment 3: make granule

[0098] Take 125 parts by weight of the borneol-one-times-hexagonal dextrin inclusion compound of Example 2, 1134 parts by weight of the dry paste fine powder of Example 1 and an appropriate amount of sodium carboxymethyl starch, mix well, make granules, dry below 60°C, and dry for 40 Mesh sieve for granulation to obtain granules.

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Abstract

The invention discloses a medicinal composition which is prepared by the following bulk pharmaceutical chemicals of scutellaria baicalensis, honeysuckle, thunder god vine, radix zanthoxyli, bark of ash, polygonum cuspidatum, radix aconiti lateralis preparata, angelica sinensis, white pepper, rheum officinale, gallnut, borneol and liquorice. Conventional auxiliary materials or an excipient can be added in medicinal composition, an extractive and a refining matter to prepare preparation such as injection, a fogging agent, a tablet, a capsule and an oral solution. The medicinal composition has functions of clearing away heat and toxic materials, tonifying spleen and warming the kidney, promoting blood circulation to arrest pain and conducting immune adjustment, is used for therapy or adjuvant therapy of the aids, can obviously improve SD4+ cell quantity and SD4+ / SD8+ ratio of HIV / AIDS patient, and improves or stabilizes immunologic functions of aids patients.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine preparation, in particular to a pharmaceutical composition for treating or adjuvantly treating AIDS and its preparation method and application. Background technique [0002] AIDS (AIDS) is an infectious disease that seriously threatens people's health. Its fatality rate is extremely high. At present, there is no effective vaccine for prevention and no cure. Seriously hindering social development has become a social problem that governments of all countries pay close attention to. Just as my country's Ministry of Health, State Planning Commission, Ministry of Science and Technology, and Ministry of Finance jointly formulated the "China's Medium- and Long-term Plan for AIDS Prevention and Control" (1998-2010), it said: "Prevention and control of AIDS is an urgent, complex and long-term arduous task. task” and believes that currently “there is a lack of effective experience and methods for t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61P31/18A61K31/045A61K35/64
Inventor 宋福德周国泰
Owner 宋福德
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